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- W2131873754 abstract "Baicalin is a flavonoid compound extracted from Scutellaria roots that has been reported to possess antibacterial, anti-inflammatory, and antiviral activities. However, the antiviral effect of baicalin on enterovirus 71 (EV71) is still unknown. In this study, we found that baicalin showed inhibitory activity on EV71 infection and was independent of direct virucidal or prophylactic effect and inhibitory viral absorption. The expressions of EV71/3D mRNA and polymerase were significantly blocked by baicalin treatment at early stages of EV71 infection. In addition, baicalin could decrease the expressions of FasL and caspase-3, as well as inhibit the apoptosis of EV71-infected human embryonal rhabdomyosarcoma (RD) cells. Altogether, these results indicate that baicalin exhibits potent antiviral effect on EV71 infection, probably through inhibiting EV71/3D polymerase expression and Fas/FasL signaling pathways." @default.
- W2131873754 created "2016-06-24" @default.
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- W2131873754 date "2015-08-19" @default.
- W2131873754 modified "2023-10-03" @default.
- W2131873754 title "The Antiviral Effect of Baicalin on Enterovirus 71 In Vitro" @default.
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- W2131873754 doi "https://doi.org/10.3390/v7082841" @default.
- W2131873754 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4576202" @default.
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