FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2131886856> ?p ?o ?g. }

• W2131886856 abstract "The human dopamine transporter (DAT, SLC6A3) has been extensively investigated because of its potential involvement in neuropsychiatric disorders. The core elements responsible for its transcription have been identified. A regulatory role for certain genomic variants upstream to the core promoter is known. Recently, other single-nucleotide polymorphisms (SNPs) have been identified in this region and are thought to be associated with schizophrenia and bipolar I disorder. Hence, we have investigated the impact of common SNPs in a 2.8-kilobase region flanking the core promoter region (-2.7 to +63 base pair) in the neuroblastoma cell line SH-SY5Y. Haplotypes generated by site-directed mutagenesis revealed varying impact of individual SNPs on promoter activity using dual luciferase assays. In silico analyses also predicted allele-specific binding of transcription factors for some of these SNPs. Though electrophoretic mobility shift assays indicated several factors that appeared to bind to specific sites within this region, allele-specific binding was not detected for any SNP apart from rs3756450. We have thus identified novel putative regulatory domains flanking the core promoter of DAT that merit further investigation." @default.
• W2131886856 created "2016-06-24" @default.
• W2131886856 creator A5053027273 @default.
• W2131886856 creator A5060291693 @default.
• W2131886856 creator A5064740533 @default.
• W2131886856 creator A5088260835 @default.
• W2131886856 date "2009-03-09" @default.
• W2131886856 modified "2023-09-25" @default.
• W2131886856 title "Functional Analysis of Upstream Common Polymorphisms of the Dopamine Transporter Gene" @default.
• W2131886856 cites W1488447589 @default.
• W2131886856 cites W1544307004 @default.
• W2131886856 cites W1964469331 @default.
• W2131886856 cites W1982498939 @default.
• W2131886856 cites W1987385327 @default.
• W2131886856 cites W1990556558 @default.
• W2131886856 cites W2018580557 @default.
• W2131886856 cites W2032119990 @default.
• W2131886856 cites W2037023405 @default.
• W2131886856 cites W2039739492 @default.
• W2131886856 cites W2041371320 @default.
• W2131886856 cites W2059949526 @default.
• W2131886856 cites W2064879068 @default.
• W2131886856 cites W2070924027 @default.
• W2131886856 cites W2079204641 @default.
• W2131886856 cites W2089220633 @default.
• W2131886856 cites W2094646101 @default.
• W2131886856 cites W2098542074 @default.
• W2131886856 cites W2101322261 @default.
• W2131886856 cites W2103031960 @default.
• W2131886856 cites W2114011270 @default.
• W2131886856 cites W2130988047 @default.
• W2131886856 cites W2145533695 @default.
• W2131886856 doi "https://doi.org/10.1093/schbul/sbp005" @default.
• W2131886856 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2930346" @default.
• W2131886856 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19273584" @default.
• W2131886856 hasPublicationYear "2009" @default.
• W2131886856 type Work @default.
• W2131886856 sameAs 2131886856 @default.
• W2131886856 citedByCount "9" @default.
• W2131886856 countsByYear W21318868562013 @default.
• W2131886856 countsByYear W21318868562014 @default.
• W2131886856 countsByYear W21318868562015 @default.
• W2131886856 countsByYear W21318868562019 @default.
• W2131886856 countsByYear W21318868562020 @default.
• W2131886856 crossrefType "journal-article" @default.
• W2131886856 hasAuthorship W2131886856A5053027273 @default.
• W2131886856 hasAuthorship W2131886856A5060291693 @default.
• W2131886856 hasAuthorship W2131886856A5064740533 @default.
• W2131886856 hasAuthorship W2131886856A5088260835 @default.
• W2131886856 hasBestOaLocation W21318868561 @default.
• W2131886856 hasConcept C101762097 @default.
• W2131886856 hasConcept C104317684 @default.
• W2131886856 hasConcept C135763542 @default.
• W2131886856 hasConcept C139275648 @default.
• W2131886856 hasConcept C149011108 @default.
• W2131886856 hasConcept C150194340 @default.
• W2131886856 hasConcept C153209595 @default.
• W2131886856 hasConcept C180754005 @default.
• W2131886856 hasConcept C183978625 @default.
• W2131886856 hasConcept C186493320 @default.
• W2131886856 hasConcept C197754878 @default.
• W2131886856 hasConcept C2776755682 @default.
• W2131886856 hasConcept C54355233 @default.
• W2131886856 hasConcept C84597430 @default.
• W2131886856 hasConcept C86339819 @default.
• W2131886856 hasConcept C86803240 @default.
• W2131886856 hasConceptScore W2131886856C101762097 @default.
• W2131886856 hasConceptScore W2131886856C104317684 @default.
• W2131886856 hasConceptScore W2131886856C135763542 @default.
• W2131886856 hasConceptScore W2131886856C139275648 @default.
• W2131886856 hasConceptScore W2131886856C149011108 @default.
• W2131886856 hasConceptScore W2131886856C150194340 @default.
• W2131886856 hasConceptScore W2131886856C153209595 @default.
• W2131886856 hasConceptScore W2131886856C180754005 @default.
• W2131886856 hasConceptScore W2131886856C183978625 @default.
• W2131886856 hasConceptScore W2131886856C186493320 @default.
• W2131886856 hasConceptScore W2131886856C197754878 @default.
• W2131886856 hasConceptScore W2131886856C2776755682 @default.
• W2131886856 hasConceptScore W2131886856C54355233 @default.
• W2131886856 hasConceptScore W2131886856C84597430 @default.
• W2131886856 hasConceptScore W2131886856C86339819 @default.
• W2131886856 hasConceptScore W2131886856C86803240 @default.
• W2131886856 hasLocation W21318868561 @default.
• W2131886856 hasLocation W21318868562 @default.
• W2131886856 hasLocation W21318868563 @default.
• W2131886856 hasLocation W21318868564 @default.
• W2131886856 hasLocation W21318868565 @default.
• W2131886856 hasOpenAccess W2131886856 @default.
• W2131886856 hasPrimaryLocation W21318868561 @default.
• W2131886856 hasRelatedWork W1968406655 @default.
• W2131886856 hasRelatedWork W1981708330 @default.
• W2131886856 hasRelatedWork W1991294463 @default.
• W2131886856 hasRelatedWork W1998620232 @default.
• W2131886856 hasRelatedWork W2008370561 @default.
• W2131886856 hasRelatedWork W2026794105 @default.
• W2131886856 hasRelatedWork W2031308320 @default.
• W2131886856 hasRelatedWork W2035405715 @default.
• W2131886856 hasRelatedWork W2039022137 @default.
• W2131886856 hasRelatedWork W2049088703 @default.
• W2131886856 hasRelatedWork W2058101319 @default.

• next