FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2131908334> ?p ?o ?g. }

• W2131908334 endingPage "2205" @default.
• W2131908334 startingPage "2187" @default.
• W2131908334 abstract "The objective of this study was to investigate whether metabolic activation of parathion by cytochrome P-450s (CYPs) was responsible for pesticide-induced hepatotoxicity and immunotoxicity. Initially, to investigate parathion metabolism in vitro, the production of paraoxon and p-nitrophenol, major metabolites of parathion, was determined by high-performance liquid chromatography (HPLC). Subsequently, metabolic fate and CYP enzymes involved in the metabolism of parathion were partially monitored in rat liver microsomes in the presence of the NADPH-generating system. Among others, phenobarbital (PB)-induced microsomes produced the metabolites paraoxon and p-nitrophenol to the greatest extent, indicating the involvement of CYP 2B in parathion metabolism. When female BALB/c mice were treated orally with 1, 4, or 16 mg/kg of parathion in corn oil once, parathion suppressed the antibody response to sheep red blood cells. To further investigate a possible role of metabolic activation by CYP enzymes in parathion-induced toxicity, female BALB/c mice were pretreated intraperitoneally with 40 mg/kg PB for 3 d, followed by a single oral treatment with 16 mg/kg parathion. PB pretreatment produced a decrease in hepatic glutathione content and increases in hepatotoxic paramenters in parathion-treated mice with no changes in the antibody response. In addition, greater p-nitrophenol amounts were produced when mice were pretreated with PB, compared to treatment with parathion alone. These results indicate that parathion-induced hepatotoxicity might be differentiated from immunotoxicity in mice." @default.
• W2131908334 created "2016-06-24" @default.
• W2131908334 creator A5007198262 @default.
• W2131908334 creator A5020911038 @default.
• W2131908334 creator A5022918002 @default.
• W2131908334 creator A5025853867 @default.
• W2131908334 creator A5027814766 @default.
• W2131908334 creator A5032843094 @default.
• W2131908334 creator A5047995856 @default.
• W2131908334 creator A5055015781 @default.
• W2131908334 creator A5055083737 @default.
• W2131908334 creator A5059370020 @default.
• W2131908334 creator A5061055489 @default.
• W2131908334 creator A5069457471 @default.
• W2131908334 date "2005-12-01" @default.
• W2131908334 modified "2023-09-23" @default.
• W2131908334 title "Role of Metabolism in Parathion-Induced Hepatotoxicity and Immunotoxicity" @default.
• W2131908334 cites W1775749144 @default.
• W2131908334 cites W1973655326 @default.
• W2131908334 cites W1980061134 @default.
• W2131908334 cites W1985324060 @default.
• W2131908334 cites W1986104287 @default.
• W2131908334 cites W1987492742 @default.
• W2131908334 cites W1990913988 @default.
• W2131908334 cites W1992382406 @default.
• W2131908334 cites W1996143925 @default.
• W2131908334 cites W2002890456 @default.
• W2131908334 cites W2006370393 @default.
• W2131908334 cites W2007738922 @default.
• W2131908334 cites W2010770851 @default.
• W2131908334 cites W2022865333 @default.
• W2131908334 cites W2032551881 @default.
• W2131908334 cites W2033247996 @default.
• W2131908334 cites W2044412372 @default.
• W2131908334 cites W2044659011 @default.
• W2131908334 cites W2049613518 @default.
• W2131908334 cites W2049754390 @default.
• W2131908334 cites W2050678950 @default.
• W2131908334 cites W2067101142 @default.
• W2131908334 cites W2067715785 @default.
• W2131908334 cites W2074530946 @default.
• W2131908334 cites W2078362738 @default.
• W2131908334 cites W2081927835 @default.
• W2131908334 cites W2082921092 @default.
• W2131908334 cites W2085566853 @default.
• W2131908334 cites W2087111838 @default.
• W2131908334 cites W2088673439 @default.
• W2131908334 cites W2093341492 @default.
• W2131908334 cites W2152061402 @default.
• W2131908334 doi "https://doi.org/10.1080/15287390500180549" @default.
• W2131908334 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16326433" @default.
• W2131908334 hasPublicationYear "2005" @default.
• W2131908334 type Work @default.
• W2131908334 sameAs 2131908334 @default.
• W2131908334 citedByCount "18" @default.
• W2131908334 countsByYear W21319083342012 @default.
• W2131908334 countsByYear W21319083342018 @default.
• W2131908334 countsByYear W21319083342019 @default.
• W2131908334 countsByYear W21319083342021 @default.
• W2131908334 countsByYear W21319083342022 @default.
• W2131908334 crossrefType "journal-article" @default.
• W2131908334 hasAuthorship W2131908334A5007198262 @default.
• W2131908334 hasAuthorship W2131908334A5020911038 @default.
• W2131908334 hasAuthorship W2131908334A5022918002 @default.
• W2131908334 hasAuthorship W2131908334A5025853867 @default.
• W2131908334 hasAuthorship W2131908334A5027814766 @default.
• W2131908334 hasAuthorship W2131908334A5032843094 @default.
• W2131908334 hasAuthorship W2131908334A5047995856 @default.
• W2131908334 hasAuthorship W2131908334A5055015781 @default.
• W2131908334 hasAuthorship W2131908334A5055083737 @default.
• W2131908334 hasAuthorship W2131908334A5059370020 @default.
• W2131908334 hasAuthorship W2131908334A5061055489 @default.
• W2131908334 hasAuthorship W2131908334A5069457471 @default.
• W2131908334 hasConcept C161176658 @default.
• W2131908334 hasConcept C178790620 @default.
• W2131908334 hasConcept C181199279 @default.
• W2131908334 hasConcept C185592680 @default.
• W2131908334 hasConcept C2777207434 @default.
• W2131908334 hasConcept C2777565064 @default.
• W2131908334 hasConcept C2778816929 @default.
• W2131908334 hasConcept C29730261 @default.
• W2131908334 hasConcept C526171541 @default.
• W2131908334 hasConcept C55493867 @default.
• W2131908334 hasConcept C62231903 @default.
• W2131908334 hasConcept C6557445 @default.
• W2131908334 hasConcept C86803240 @default.
• W2131908334 hasConcept C87644729 @default.
• W2131908334 hasConcept C98274493 @default.
• W2131908334 hasConceptScore W2131908334C161176658 @default.
• W2131908334 hasConceptScore W2131908334C178790620 @default.
• W2131908334 hasConceptScore W2131908334C181199279 @default.
• W2131908334 hasConceptScore W2131908334C185592680 @default.
• W2131908334 hasConceptScore W2131908334C2777207434 @default.
• W2131908334 hasConceptScore W2131908334C2777565064 @default.
• W2131908334 hasConceptScore W2131908334C2778816929 @default.
• W2131908334 hasConceptScore W2131908334C29730261 @default.
• W2131908334 hasConceptScore W2131908334C526171541 @default.
• W2131908334 hasConceptScore W2131908334C55493867 @default.

• next