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- W2131909949 abstract "A chimeric receptor composed of the extracellular domain of the human T-cell antigen CD2 (T11) joined to the membrane-spanning segment and the intracellular tyrosine kinase domain of the human colony-stimulating factor 1 receptor (CSF-1R) was expressed in murine NIH 3T3 fibroblasts. Stimulation of these cells with monoclonal antibodies to CD2 induced phosphorylation of the chimeric glycoprotein on tyrosine, receptor downmodulation, and mitogenesis. In contrast, neither human CSF-1R nor the chimeric receptor was able to function in interleukin-2-dependent murine T cells. In fibroblasts, then, CSF-1 per se is not required for activation of the receptor kinase or for a biological response, whereas in T cells, CSF-1R may be unable to engage the downstream signal transduction machinery." @default.
- W2131909949 created "2016-06-24" @default.
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- W2131909949 date "1990-05-01" @default.
- W2131909949 modified "2023-09-27" @default.
- W2131909949 title "Antibody-induced mitogenicity mediated by a chimeric CD2-c-fms receptor." @default.
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- W2131909949 doi "https://doi.org/10.1128/mcb.10.5.2407" @default.
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