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• W2131921856 abstract "Label-free LC-MS methods are attractive for high-throughput quantitative proteomics, as the sample processing is straightforward and can be scaled to a large number of samples. Label-free methods therefore facilitate biomarker discovery in studies involving dozens of clinical samples. However, despite the increased popularity of label-free workflows, there is a hesitance in the research community to use it in clinical proteomics studies. Therefore, we here discuss pros and cons of label-free LC-MS/MS for biomarker discovery, and delineate the main prerequisites for its successful employment. Furthermore, we cite studies where label-free LC-MS/MS was successfully used to identify novel biomarkers, and foresee an increased acceptance of label-free techniques by the proteomics community in the near future." @default.
• W2131921856 created "2016-06-24" @default.
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• W2131921856 date "2015-03-21" @default.
• W2131921856 modified "2023-10-14" @default.
• W2131921856 title "Is label-free LC-MS/MS ready for biomarker discovery?" @default.
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• W2131921856 doi "https://doi.org/10.1002/prca.201400202" @default.
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