FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2131967029> ?p ?o ?g. }

• W2131967029 endingPage "699" @default.
• W2131967029 startingPage "689" @default.
• W2131967029 abstract "The activities of intracellular receptors are regulated by their cognate ligands. Here we show that a series of related arylpyrazole compounds, which specifically bind the glucocorticoid receptor (GR), selectively modulated GR-regulated biological functions in preadipocyte, preosteoblast, and lung epithelial cell lines. Indeed, when we monitored 17 endogenous GR target genes in one of these cell types, we found that distinct arylpyrazole compounds induced different expression patterns. We showed by chromatin immunoprecipitation that the arylpyrazole compounds regulated, in a gene-specific manner, either GR occupancy of the genomic glucocorticoid response element (GRE) or events after GR association, such as histone modification. Overall, our results establish that subtle differences in ligand chemistry can profoundly influence the transcriptional regulatory activity of GR, and that endogenous genes bearing natural GREs are especially sensitive detectors of these differences." @default.
• W2131967029 created "2016-06-24" @default.
• W2131967029 creator A5009598129 @default.
• W2131967029 creator A5017706607 @default.
• W2131967029 creator A5032224690 @default.
• W2131967029 creator A5039962473 @default.
• W2131967029 creator A5071406734 @default.
• W2131967029 creator A5073292373 @default.
• W2131967029 creator A5081991449 @default.
• W2131967029 date "2006-03-15" @default.
• W2131967029 modified "2023-09-24" @default.
• W2131967029 title "Novel arylpyrazole compounds selectively modulate glucocorticoid receptor regulatory activity" @default.
• W2131967029 cites W1632044028 @default.
• W2131967029 cites W1966538470 @default.
• W2131967029 cites W1967913337 @default.
• W2131967029 cites W1968154721 @default.
• W2131967029 cites W1980292048 @default.
• W2131967029 cites W1982283061 @default.
• W2131967029 cites W1988396057 @default.
• W2131967029 cites W1997103341 @default.
• W2131967029 cites W2003465691 @default.
• W2131967029 cites W2003797217 @default.
• W2131967029 cites W2007984040 @default.
• W2131967029 cites W2008944557 @default.
• W2131967029 cites W2017780187 @default.
• W2131967029 cites W2032417358 @default.
• W2131967029 cites W2035254675 @default.
• W2131967029 cites W2042143409 @default.
• W2131967029 cites W2045389096 @default.
• W2131967029 cites W2052461244 @default.
• W2131967029 cites W2074470455 @default.
• W2131967029 cites W2079105050 @default.
• W2131967029 cites W2103954396 @default.
• W2131967029 cites W2104360623 @default.
• W2131967029 cites W2119725374 @default.
• W2131967029 cites W2128177613 @default.
• W2131967029 cites W2134055375 @default.
• W2131967029 cites W2140504667 @default.
• W2131967029 cites W2151150922 @default.
• W2131967029 cites W2160772803 @default.
• W2131967029 cites W2162119791 @default.
• W2131967029 cites W2163459063 @default.
• W2131967029 cites W2166084959 @default.
• W2131967029 cites W2171666794 @default.
• W2131967029 cites W2181304582 @default.
• W2131967029 cites W2416747940 @default.
• W2131967029 cites W2950609156 @default.
• W2131967029 doi "https://doi.org/10.1101/gad.1400506" @default.
• W2131967029 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1413289" @default.
• W2131967029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16543221" @default.
• W2131967029 hasPublicationYear "2006" @default.
• W2131967029 type Work @default.
• W2131967029 sameAs 2131967029 @default.
• W2131967029 citedByCount "88" @default.
• W2131967029 countsByYear W21319670292012 @default.
• W2131967029 countsByYear W21319670292013 @default.
• W2131967029 countsByYear W21319670292014 @default.
• W2131967029 countsByYear W21319670292015 @default.
• W2131967029 countsByYear W21319670292016 @default.
• W2131967029 countsByYear W21319670292017 @default.
• W2131967029 countsByYear W21319670292018 @default.
• W2131967029 countsByYear W21319670292019 @default.
• W2131967029 countsByYear W21319670292021 @default.
• W2131967029 countsByYear W21319670292022 @default.
• W2131967029 countsByYear W21319670292023 @default.
• W2131967029 crossrefType "journal-article" @default.
• W2131967029 hasAuthorship W2131967029A5009598129 @default.
• W2131967029 hasAuthorship W2131967029A5017706607 @default.
• W2131967029 hasAuthorship W2131967029A5032224690 @default.
• W2131967029 hasAuthorship W2131967029A5039962473 @default.
• W2131967029 hasAuthorship W2131967029A5071406734 @default.
• W2131967029 hasAuthorship W2131967029A5073292373 @default.
• W2131967029 hasAuthorship W2131967029A5081991449 @default.
• W2131967029 hasBestOaLocation W21319670291 @default.
• W2131967029 hasConcept C101762097 @default.
• W2131967029 hasConcept C104317684 @default.
• W2131967029 hasConcept C121608353 @default.
• W2131967029 hasConcept C134018914 @default.
• W2131967029 hasConcept C134320426 @default.
• W2131967029 hasConcept C150194340 @default.
• W2131967029 hasConcept C165864922 @default.
• W2131967029 hasConcept C16613235 @default.
• W2131967029 hasConcept C170493617 @default.
• W2131967029 hasConcept C2780841215 @default.
• W2131967029 hasConcept C51445715 @default.
• W2131967029 hasConcept C530470458 @default.
• W2131967029 hasConcept C54355233 @default.
• W2131967029 hasConcept C55493867 @default.
• W2131967029 hasConcept C59493245 @default.
• W2131967029 hasConcept C63932345 @default.
• W2131967029 hasConcept C64927066 @default.
• W2131967029 hasConcept C79879829 @default.
• W2131967029 hasConcept C83640560 @default.
• W2131967029 hasConcept C84606932 @default.
• W2131967029 hasConcept C86339819 @default.
• W2131967029 hasConcept C86803240 @default.
• W2131967029 hasConcept C95444343 @default.
• W2131967029 hasConceptScore W2131967029C101762097 @default.

• next