FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2131970705> ?p ?o ?g. }

• W2131970705 endingPage "994" @default.
• W2131970705 startingPage "981" @default.
• W2131970705 abstract "Polyclonal plaque-forming cell (PFC) responses in murine spleen cells induced by Staphylococcus aureus and S. epidermidis were studied. Injection of Balb/c mice with S. aureus strain 248βH resulted in the generation of anti-trinitrophenyl (TNP) and anti-sheep red blood cell PFC in their spleens. Cultures of Balb/c spleen cells in the presence of S. aureus 248βH, Cowan I, or a protein A-deficient mutant yielded many anti-TNP PFC. The larger the number of organisms that were added to the cultures, the better was the PFC response. Both living and killed organisms, were capable of inducing the response, but an excess of living 248βH organisms in the cultures abrogated the response. All of the organisms (12 strains of S. aureus and 11 strains of S. epidermidis) freshly isolated from patients had the ability to induce the polyclonal PFC response in cell cultures. These organisms stimulated cultured C3H/HeJ mouse spleen cells, which were unresponsive to bacterial lipopolysaccharide (LPS). Cultured cells from the spleens of athymic nu/nu mice also responded to these organisms, and the number of PFC in nu/nu cell cultures was always greater than that in nu/+ cells prepared from a haired litter mate. Moreover, the responses of nu/nu spleen cell cultures to which nylon wool column-filtered splenic nu/+ T cells were added were lower than expected. These findings suggest that the polyclonal PFC response to staphylococci is thymus independent, but that the magnitude of the response is regulated by mature T cells. Cultures of macrophage-depleted spleen cells responded to the organisms to an extent similar to that of the control. The 248βH organisms were less capable of stimulating spleen cells of 2-week-old mice (i.e., early maturing B cells) than LPS. However, spleen cells from adult (7-week-old) and aged (9-month-old) mice responded well to both the organisms and LPS. Previous sensitization with the organisms in vivo did not affect any polyclonal responses of spleen cells in vitro to either the organisms or LPS. The role of staphylococcal protein A in the polyclonal PFC response to staphylococci is discussed." @default.
• W2131970705 created "2016-06-24" @default.
• W2131970705 creator A5007728006 @default.
• W2131970705 creator A5008123496 @default.
• W2131970705 creator A5013668839 @default.
• W2131970705 creator A5062061559 @default.
• W2131970705 creator A5063862039 @default.
• W2131970705 date "1980-10-01" @default.
• W2131970705 modified "2023-10-18" @default.
• W2131970705 title "Polyclonal Antibody Production in Murine Spleen Cells Induced by Staphylococcus" @default.
• W2131970705 cites W1484285187 @default.
• W2131970705 cites W1525963692 @default.
• W2131970705 cites W1559061871 @default.
• W2131970705 cites W1594085931 @default.
• W2131970705 cites W1602108904 @default.
• W2131970705 cites W1838865082 @default.
• W2131970705 cites W1873518558 @default.
• W2131970705 cites W1964532737 @default.
• W2131970705 cites W1993930516 @default.
• W2131970705 cites W1994753721 @default.
• W2131970705 cites W2009224297 @default.
• W2131970705 cites W2018324362 @default.
• W2131970705 cites W2032840352 @default.
• W2131970705 cites W2046005858 @default.
• W2131970705 cites W2057572787 @default.
• W2131970705 cites W2064058648 @default.
• W2131970705 cites W2084093106 @default.
• W2131970705 cites W2110424801 @default.
• W2131970705 cites W2112508166 @default.
• W2131970705 cites W2118856421 @default.
• W2131970705 cites W2122775596 @default.
• W2131970705 cites W2123163342 @default.
• W2131970705 cites W2133896601 @default.
• W2131970705 cites W2148757469 @default.
• W2131970705 cites W2157002219 @default.
• W2131970705 cites W2329211716 @default.
• W2131970705 cites W4313305987 @default.
• W2131970705 cites W4313310622 @default.
• W2131970705 cites W4321829298 @default.
• W2131970705 doi "https://doi.org/10.1111/j.1348-0421.1980.tb02903.x" @default.
• W2131970705 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6970323" @default.
• W2131970705 hasPublicationYear "1980" @default.
• W2131970705 type Work @default.
• W2131970705 sameAs 2131970705 @default.
• W2131970705 citedByCount "4" @default.
• W2131970705 crossrefType "journal-article" @default.
• W2131970705 hasAuthorship W2131970705A5007728006 @default.
• W2131970705 hasAuthorship W2131970705A5008123496 @default.
• W2131970705 hasAuthorship W2131970705A5013668839 @default.
• W2131970705 hasAuthorship W2131970705A5062061559 @default.
• W2131970705 hasAuthorship W2131970705A5063862039 @default.
• W2131970705 hasBestOaLocation W21319707051 @default.
• W2131970705 hasConcept C153911025 @default.
• W2131970705 hasConcept C159654299 @default.
• W2131970705 hasConcept C189976730 @default.
• W2131970705 hasConcept C203014093 @default.
• W2131970705 hasConcept C2778754761 @default.
• W2131970705 hasConcept C2779489039 @default.
• W2131970705 hasConcept C2780931953 @default.
• W2131970705 hasConcept C523546767 @default.
• W2131970705 hasConcept C54355233 @default.
• W2131970705 hasConcept C81885089 @default.
• W2131970705 hasConcept C86803240 @default.
• W2131970705 hasConcept C89423630 @default.
• W2131970705 hasConcept C956191 @default.
• W2131970705 hasConceptScore W2131970705C153911025 @default.
• W2131970705 hasConceptScore W2131970705C159654299 @default.
• W2131970705 hasConceptScore W2131970705C189976730 @default.
• W2131970705 hasConceptScore W2131970705C203014093 @default.
• W2131970705 hasConceptScore W2131970705C2778754761 @default.
• W2131970705 hasConceptScore W2131970705C2779489039 @default.
• W2131970705 hasConceptScore W2131970705C2780931953 @default.
• W2131970705 hasConceptScore W2131970705C523546767 @default.
• W2131970705 hasConceptScore W2131970705C54355233 @default.
• W2131970705 hasConceptScore W2131970705C81885089 @default.
• W2131970705 hasConceptScore W2131970705C86803240 @default.
• W2131970705 hasConceptScore W2131970705C89423630 @default.
• W2131970705 hasConceptScore W2131970705C956191 @default.
• W2131970705 hasIssue "10" @default.
• W2131970705 hasLocation W21319707051 @default.
• W2131970705 hasLocation W21319707052 @default.
• W2131970705 hasOpenAccess W2131970705 @default.
• W2131970705 hasPrimaryLocation W21319707051 @default.
• W2131970705 hasRelatedWork W1504319559 @default.
• W2131970705 hasRelatedWork W2056400769 @default.
• W2131970705 hasRelatedWork W2072604399 @default.
• W2131970705 hasRelatedWork W2360587303 @default.
• W2131970705 hasRelatedWork W2410889971 @default.
• W2131970705 hasRelatedWork W2470704817 @default.
• W2131970705 hasRelatedWork W2472042789 @default.
• W2131970705 hasRelatedWork W3029908218 @default.
• W2131970705 hasRelatedWork W3031502370 @default.
• W2131970705 hasRelatedWork W8052553 @default.
• W2131970705 hasVolume "24" @default.
• W2131970705 isParatext "false" @default.
• W2131970705 isRetracted "false" @default.
• W2131970705 magId "2131970705" @default.
• W2131970705 workType "article" @default.