FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2132016263> ?p ?o ?g. }

• W2132016263 endingPage "226" @default.
• W2132016263 startingPage "216" @default.
• W2132016263 abstract "We analysed by immunocytochemistry metalloproteinase (MMP)-2 and MMP-9 expression in bone marrow cells from 54 acute myeloid leukaemia (AML) patients, 153 myelodysplastic syndrome (MDS) patients, and 52 non-haemopathic subjects, in order to evaluate whether MMP expression abnormalities were associated with relevant laboratory or clinical findings. In normal samples MMP-2 was detected in rare myeloid cells, MMP-9 in most maturing myeloid cells. In MDS MMP-2 myeloid levels were higher than in controls (P < 0.0001); MMP-2 and MMP-9 were often co-expressed. Also many erythroblasts expressed MMP-2. There was a positive correlation between MMP-2 erythroblast expression and erythroid dysplasia (P = 0.002) and an inverse correlation between MMP-2 or MMP-9 myeloid expression and blast cell percentage (P = 0.05 and P = 0.04 respectively). High MMP levels in myeloid cells were associated with longer overall survival (P = 0.03) and evolution-free survival (P = 0.04). In AML MMP-2 levels were lower than in MDS (P < 0.0001) and MMP-9 levels lower than in MDS and controls (P < 0.0001). MMP levels did not predict response to therapy. The release of active MMPs was detected by colorimetric analysis in cell cultures from representative MDS and AML cases. In conclusion, we have demonstrated an abnormal MMP expression in AML as well as in MDS. The production and release of these enzymes may influence haematopoietic cell behaviour. In MDS, the detection of MMP deregulated expression may be important also from the clinical point of view: it may provide a useful tool for diagnosis, prognosis and a possible target for experimental treatments." @default.
• W2132016263 created "2016-06-24" @default.
• W2132016263 creator A5019241495 @default.
• W2132016263 creator A5030156947 @default.
• W2132016263 creator A5042562332 @default.
• W2132016263 creator A5050011235 @default.
• W2132016263 creator A5072513476 @default.
• W2132016263 creator A5074405636 @default.
• W2132016263 creator A5080475851 @default.
• W2132016263 creator A5085472799 @default.
• W2132016263 creator A5090912200 @default.
• W2132016263 date "2008-03-01" @default.
• W2132016263 modified "2023-10-02" @default.
• W2132016263 title "Biological and clinical relevance of matrix metalloproteinases 2 and 9 in acute myeloid leukaemias and myelodysplastic syndromes" @default.
• W2132016263 cites W1491678226 @default.
• W2132016263 cites W1595837679 @default.
• W2132016263 cites W187238933 @default.
• W2132016263 cites W190590421 @default.
• W2132016263 cites W1963681491 @default.
• W2132016263 cites W1964138393 @default.
• W2132016263 cites W1969133782 @default.
• W2132016263 cites W1972028081 @default.
• W2132016263 cites W1973090023 @default.
• W2132016263 cites W1978035165 @default.
• W2132016263 cites W1980829846 @default.
• W2132016263 cites W1984483611 @default.
• W2132016263 cites W1992077516 @default.
• W2132016263 cites W2003500892 @default.
• W2132016263 cites W2006199182 @default.
• W2132016263 cites W2011134969 @default.
• W2132016263 cites W2016675217 @default.
• W2132016263 cites W2020546557 @default.
• W2132016263 cites W2026111144 @default.
• W2132016263 cites W2028379046 @default.
• W2132016263 cites W2033725315 @default.
• W2132016263 cites W2066775791 @default.
• W2132016263 cites W2069915122 @default.
• W2132016263 cites W2078435909 @default.
• W2132016263 cites W2084944550 @default.
• W2132016263 cites W2086790430 @default.
• W2132016263 cites W2092364178 @default.
• W2132016263 cites W2114736117 @default.
• W2132016263 cites W2156144595 @default.
• W2132016263 cites W2166580226 @default.
• W2132016263 cites W2167709602 @default.
• W2132016263 cites W2171833279 @default.
• W2132016263 cites W2262250683 @default.
• W2132016263 cites W2318586940 @default.
• W2132016263 cites W2413041165 @default.
• W2132016263 cites W4250908540 @default.
• W2132016263 doi "https://doi.org/10.1111/j.1600-0609.2007.01012.x" @default.
• W2132016263 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18081721" @default.
• W2132016263 hasPublicationYear "2008" @default.
• W2132016263 type Work @default.
• W2132016263 sameAs 2132016263 @default.
• W2132016263 citedByCount "38" @default.
• W2132016263 countsByYear W21320162632012 @default.
• W2132016263 countsByYear W21320162632013 @default.
• W2132016263 countsByYear W21320162632014 @default.
• W2132016263 countsByYear W21320162632015 @default.
• W2132016263 countsByYear W21320162632016 @default.
• W2132016263 countsByYear W21320162632017 @default.
• W2132016263 countsByYear W21320162632018 @default.
• W2132016263 countsByYear W21320162632019 @default.
• W2132016263 countsByYear W21320162632021 @default.
• W2132016263 countsByYear W21320162632023 @default.
• W2132016263 crossrefType "journal-article" @default.
• W2132016263 hasAuthorship W2132016263A5019241495 @default.
• W2132016263 hasAuthorship W2132016263A5030156947 @default.
• W2132016263 hasAuthorship W2132016263A5042562332 @default.
• W2132016263 hasAuthorship W2132016263A5050011235 @default.
• W2132016263 hasAuthorship W2132016263A5072513476 @default.
• W2132016263 hasAuthorship W2132016263A5074405636 @default.
• W2132016263 hasAuthorship W2132016263A5080475851 @default.
• W2132016263 hasAuthorship W2132016263A5085472799 @default.
• W2132016263 hasAuthorship W2132016263A5090912200 @default.
• W2132016263 hasConcept C109159458 @default.
• W2132016263 hasConcept C109523444 @default.
• W2132016263 hasConcept C126322002 @default.
• W2132016263 hasConcept C142724271 @default.
• W2132016263 hasConcept C203014093 @default.
• W2132016263 hasConcept C2778729363 @default.
• W2132016263 hasConcept C2779282312 @default.
• W2132016263 hasConcept C2780007613 @default.
• W2132016263 hasConcept C2780817109 @default.
• W2132016263 hasConcept C28328180 @default.
• W2132016263 hasConcept C502942594 @default.
• W2132016263 hasConcept C54355233 @default.
• W2132016263 hasConcept C71924100 @default.
• W2132016263 hasConcept C86803240 @default.
• W2132016263 hasConceptScore W2132016263C109159458 @default.
• W2132016263 hasConceptScore W2132016263C109523444 @default.
• W2132016263 hasConceptScore W2132016263C126322002 @default.
• W2132016263 hasConceptScore W2132016263C142724271 @default.
• W2132016263 hasConceptScore W2132016263C203014093 @default.
• W2132016263 hasConceptScore W2132016263C2778729363 @default.
• W2132016263 hasConceptScore W2132016263C2779282312 @default.
• W2132016263 hasConceptScore W2132016263C2780007613 @default.

• next