Matches in SemOpenAlex for { <https://semopenalex.org/work/W2132023472> ?p ?o ?g. }
- W2132023472 endingPage "IN1" @default.
- W2132023472 startingPage "1072" @default.
- W2132023472 abstract "Recent findings suggest that Notch signaling is active in brain tumors and stem cells, and that stem cells or cells with progenitor characteristics contribute to brain tumor formation. These stem cells are marked by expression of several markers, including nestin, an intermediate filament protein. We have studied how the Notch signaling pathway affects nestin expression in brain tumors. We find that Notch receptors and ligands are expressed in vitro and in human samples of glioblastomas, the highest grade of malignant gliomas. In culture, Notch activity activates the nestin promoter. Activation of the Notch pathway also occurs in a glioblastoma multiforme mouse model induced by Kras, with translational regulation playing a role in Notch expression. Combined activation of Notch and Kras in wild-type nestin-expressing cells leads to their expansion within the subventricular zone and retention of proliferation and nestin expression. However, activation of Notch alone is unable to induce this cellular expansion. These data suggest that Notch may have a contributing role in the stem-like character of glioma cells." @default.
- W2132023472 created "2016-06-24" @default.
- W2132023472 creator A5073337663 @default.
- W2132023472 creator A5076104674 @default.
- W2132023472 date "2006-12-01" @default.
- W2132023472 modified "2023-10-13" @default.
- W2132023472 title "Notch Signaling Enhances Nestin Expression in Gliomas" @default.
- W2132023472 cites W1675105744 @default.
- W2132023472 cites W1968614642 @default.
- W2132023472 cites W1972290939 @default.
- W2132023472 cites W1972700706 @default.
- W2132023472 cites W1979755285 @default.
- W2132023472 cites W1984637659 @default.
- W2132023472 cites W1998592999 @default.
- W2132023472 cites W2001544973 @default.
- W2132023472 cites W2010677999 @default.
- W2132023472 cites W2011341845 @default.
- W2132023472 cites W2027453759 @default.
- W2132023472 cites W2027645065 @default.
- W2132023472 cites W2030083720 @default.
- W2132023472 cites W2042838513 @default.
- W2132023472 cites W2043834555 @default.
- W2132023472 cites W2044269722 @default.
- W2132023472 cites W2044484847 @default.
- W2132023472 cites W2045321966 @default.
- W2132023472 cites W2046020742 @default.
- W2132023472 cites W2051705030 @default.
- W2132023472 cites W2063639010 @default.
- W2132023472 cites W2065754676 @default.
- W2132023472 cites W2074554424 @default.
- W2132023472 cites W2083904945 @default.
- W2132023472 cites W2087431503 @default.
- W2132023472 cites W2099705390 @default.
- W2132023472 cites W2103694596 @default.
- W2132023472 cites W2104917184 @default.
- W2132023472 cites W2105844486 @default.
- W2132023472 cites W2113942802 @default.
- W2132023472 cites W2116354730 @default.
- W2132023472 cites W2117736493 @default.
- W2132023472 cites W2118109822 @default.
- W2132023472 cites W2118623951 @default.
- W2132023472 cites W2124078079 @default.
- W2132023472 cites W2129124160 @default.
- W2132023472 cites W2131799762 @default.
- W2132023472 cites W2147135997 @default.
- W2132023472 cites W2154861644 @default.
- W2132023472 cites W2162184748 @default.
- W2132023472 cites W2167808312 @default.
- W2132023472 cites W2301310480 @default.
- W2132023472 doi "https://doi.org/10.1593/neo.06526" @default.
- W2132023472 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1790729" @default.
- W2132023472 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17217625" @default.
- W2132023472 hasPublicationYear "2006" @default.
- W2132023472 type Work @default.
- W2132023472 sameAs 2132023472 @default.
- W2132023472 citedByCount "193" @default.
- W2132023472 countsByYear W21320234722012 @default.
- W2132023472 countsByYear W21320234722013 @default.
- W2132023472 countsByYear W21320234722014 @default.
- W2132023472 countsByYear W21320234722015 @default.
- W2132023472 countsByYear W21320234722016 @default.
- W2132023472 countsByYear W21320234722017 @default.
- W2132023472 countsByYear W21320234722018 @default.
- W2132023472 countsByYear W21320234722019 @default.
- W2132023472 countsByYear W21320234722020 @default.
- W2132023472 countsByYear W21320234722021 @default.
- W2132023472 countsByYear W21320234722022 @default.
- W2132023472 countsByYear W21320234722023 @default.
- W2132023472 crossrefType "journal-article" @default.
- W2132023472 hasAuthorship W2132023472A5073337663 @default.
- W2132023472 hasAuthorship W2132023472A5076104674 @default.
- W2132023472 hasBestOaLocation W21320234721 @default.
- W2132023472 hasConcept C136834591 @default.
- W2132023472 hasConcept C161879069 @default.
- W2132023472 hasConcept C201750760 @default.
- W2132023472 hasConcept C2777542384 @default.
- W2132023472 hasConcept C2777738006 @default.
- W2132023472 hasConcept C2778227246 @default.
- W2132023472 hasConcept C2780645649 @default.
- W2132023472 hasConcept C28328180 @default.
- W2132023472 hasConcept C502942594 @default.
- W2132023472 hasConcept C62478195 @default.
- W2132023472 hasConcept C86803240 @default.
- W2132023472 hasConcept C95444343 @default.
- W2132023472 hasConceptScore W2132023472C136834591 @default.
- W2132023472 hasConceptScore W2132023472C161879069 @default.
- W2132023472 hasConceptScore W2132023472C201750760 @default.
- W2132023472 hasConceptScore W2132023472C2777542384 @default.
- W2132023472 hasConceptScore W2132023472C2777738006 @default.
- W2132023472 hasConceptScore W2132023472C2778227246 @default.
- W2132023472 hasConceptScore W2132023472C2780645649 @default.
- W2132023472 hasConceptScore W2132023472C28328180 @default.
- W2132023472 hasConceptScore W2132023472C502942594 @default.
- W2132023472 hasConceptScore W2132023472C62478195 @default.
- W2132023472 hasConceptScore W2132023472C86803240 @default.
- W2132023472 hasConceptScore W2132023472C95444343 @default.
- W2132023472 hasIssue "12" @default.
- W2132023472 hasLocation W21320234721 @default.