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- W2132024508 abstract "Novel mechanisms of central nervous system damage in HIV infection Joy E Hazleton1, Joan W Berman1,2, Eliseo A Eugenin11Department of Pathology and 2Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USAAbstract: Human immunodeficiency virus-1 infection of the central nervous system is an early event after primary infection, resulting in motor and cognitive defects in a significant number of individuals despite successful antiretroviral therapy. The pathology of the infected brain is characterized by enhanced leukocyte infiltration, microglial activation and nodules, aberrant expression of inflammatory factors, neuronal dysregulation and loss, and blood–brain barrier disruption. Months to years following the primary infection, these central nervous system insults result in a spectrum of motor and cognitive dysfunction, ranging from mild impairment to frank dementia. The mechanisms that mediate impairment are still not fully defined. In this review we discuss the cellular and molecular mechanisms that facilitate impairment and new data that implicate intercellular communication systems, gap junctions and tunneling nanotubes, as mediators of human immunodeficiency virus-1 toxicity and infection within the central nervous system. These data suggest potential targets for novel therapeutics.Keywords: AIDS, dementia, inflammation, gap junctions, nanotubes, chemokines" @default.
- W2132024508 created "2016-06-24" @default.
- W2132024508 creator A5009500174 @default.
- W2132024508 creator A5046995734 @default.
- W2132024508 creator A5057650635 @default.
- W2132024508 date "2010-03-01" @default.
- W2132024508 modified "2023-10-01" @default.
- W2132024508 title "Novel mechanisms of central nervous system damage in HIV infection" @default.
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