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- W2132047592 abstract "Patients suffering from rhinitis soon tire of the relentless nasal itching, rhinorrhea, sneezing, and nasal blockage. Whether the rhinitis is atopic in nature or idiopathic, the panoply of troubling symptoms remains constant. These symptoms, as a whole, speak directly to disease mechanism. The symptoms of rhinitis are what one would expect if there were inappropriate activity in the trigeminal afferent (sensory) nerves innervating the nasal mucosa. Activation of these nerves would likely lead to itching, sneezing, cholinergic reflex secretions (rhinorrhea), and vasodilation (nasal blockage). The questions remain: What alters the trigeminal nervous system in rhinitis, and are the mechanisms the same between the 2 seemingly disparate disorders of allergic rhinitis and nonallergic idiopathic rhinitis? Enhanced nerve growth factor expression by mast cells does not differ significantly between idiopathic and allergic rhinitisAnnals of Allergy, Asthma & ImmunologyVol. 108Issue 6PreviewThe role of neurotrophins in allergic rhinitis (AR) has been well studied, but it has not been evaluated in idiopathic rhinitis (IR). Full-Text PDF" @default.
- W2132047592 created "2016-06-24" @default.
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- W2132047592 date "2012-09-01" @default.
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- W2132047592 title "Is nerve growth factor involved in the symptoms of rhinitis?" @default.
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- W2132047592 doi "https://doi.org/10.1016/j.anai.2012.07.011" @default.
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