Matches in SemOpenAlex for { <https://semopenalex.org/work/W2132063519> ?p ?o ?g. }
- W2132063519 endingPage "463" @default.
- W2132063519 startingPage "453" @default.
- W2132063519 abstract "Spongistatin 1 is a macrocyclic lactone polyether from the marine sponge Hyrtios erecta. The aim of this study was to evaluate the in vitro and in vivo antifungal efficacies and mechanism of spongistatin 1. Spongistatin 1 was fungicidal for the majority of 74 reference strains and clinical isolates, including those resistant to flucytosine, ketoconazole or fluconazole, and retained activity in the presence of human serum or at lowered pH. The duration of the postantifungal effect following 1 h exposure to one, four and eight times the minimal inhibitory concentration was strain-dependent. Spongistatin 1 was significantly more efficacious than amphotericin B in reducing kidney infectious burden in a murine model of disseminated candidiasis, and reduced the lung burden in a murine model of pulmonary cryptococcosis. When cryptococcal microtubules were visualized by fluorescence microscopy and iterative deconvolution, spongistatin 1 was shown to disrupt first cytoplasmic and then spindle microtubules in a time- and concentration-dependent manner. Microtubule disruption was accompanied by an abnormal distribution of nuclei in budding cells and an inhibition of cell division, resulting in cells arrested in a large-budded stage. Spongistatin 1 should be pursued as a potential antifungal agent and as a probe to study, major cellular processes." @default.
- W2132063519 created "2016-06-24" @default.
- W2132063519 creator A5006298901 @default.
- W2132063519 creator A5022830687 @default.
- W2132063519 creator A5044539366 @default.
- W2132063519 creator A5046396433 @default.
- W2132063519 creator A5053482128 @default.
- W2132063519 creator A5066809993 @default.
- W2132063519 date "2005-01-01" @default.
- W2132063519 modified "2023-09-27" @default.
- W2132063519 title "<i>In vitro</i>and<i>in vivo</i>antifungal activities of the marine sponge constituent spongistatin" @default.
- W2132063519 cites W1511582654 @default.
- W2132063519 cites W1899647266 @default.
- W2132063519 cites W1908956228 @default.
- W2132063519 cites W1968144700 @default.
- W2132063519 cites W1996380608 @default.
- W2132063519 cites W2004434620 @default.
- W2132063519 cites W2005924926 @default.
- W2132063519 cites W2020898310 @default.
- W2132063519 cites W2023956788 @default.
- W2132063519 cites W2051772698 @default.
- W2132063519 cites W2055929620 @default.
- W2132063519 cites W2057190877 @default.
- W2132063519 cites W2060971151 @default.
- W2132063519 cites W2068040039 @default.
- W2132063519 cites W2070144849 @default.
- W2132063519 cites W2087964747 @default.
- W2132063519 cites W2096791076 @default.
- W2132063519 cites W2097362646 @default.
- W2132063519 cites W2100789246 @default.
- W2132063519 cites W2104368376 @default.
- W2132063519 cites W2114605201 @default.
- W2132063519 cites W2117332681 @default.
- W2132063519 cites W2118628629 @default.
- W2132063519 cites W2127376469 @default.
- W2132063519 cites W2131421679 @default.
- W2132063519 cites W2133112673 @default.
- W2132063519 cites W2139324530 @default.
- W2132063519 cites W2139693671 @default.
- W2132063519 cites W2156949484 @default.
- W2132063519 cites W2161914902 @default.
- W2132063519 cites W2170508213 @default.
- W2132063519 cites W2172030144 @default.
- W2132063519 cites W2320342101 @default.
- W2132063519 cites W2419460916 @default.
- W2132063519 cites W4238514517 @default.
- W2132063519 cites W4297811216 @default.
- W2132063519 cites W976139268 @default.
- W2132063519 doi "https://doi.org/10.1080/13693780500050598" @default.
- W2132063519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16178375" @default.
- W2132063519 hasPublicationYear "2005" @default.
- W2132063519 type Work @default.
- W2132063519 sameAs 2132063519 @default.
- W2132063519 citedByCount "11" @default.
- W2132063519 countsByYear W21320635192014 @default.
- W2132063519 countsByYear W21320635192015 @default.
- W2132063519 countsByYear W21320635192019 @default.
- W2132063519 countsByYear W21320635192023 @default.
- W2132063519 crossrefType "journal-article" @default.
- W2132063519 hasAuthorship W2132063519A5006298901 @default.
- W2132063519 hasAuthorship W2132063519A5022830687 @default.
- W2132063519 hasAuthorship W2132063519A5044539366 @default.
- W2132063519 hasAuthorship W2132063519A5046396433 @default.
- W2132063519 hasAuthorship W2132063519A5053482128 @default.
- W2132063519 hasAuthorship W2132063519A5066809993 @default.
- W2132063519 hasBestOaLocation W21320635191 @default.
- W2132063519 hasConcept C150903083 @default.
- W2132063519 hasConcept C185592680 @default.
- W2132063519 hasConcept C202751555 @default.
- W2132063519 hasConcept C207001950 @default.
- W2132063519 hasConcept C2779548794 @default.
- W2132063519 hasConcept C2779629538 @default.
- W2132063519 hasConcept C55493867 @default.
- W2132063519 hasConcept C86803240 @default.
- W2132063519 hasConcept C89423630 @default.
- W2132063519 hasConcept C98274493 @default.
- W2132063519 hasConceptScore W2132063519C150903083 @default.
- W2132063519 hasConceptScore W2132063519C185592680 @default.
- W2132063519 hasConceptScore W2132063519C202751555 @default.
- W2132063519 hasConceptScore W2132063519C207001950 @default.
- W2132063519 hasConceptScore W2132063519C2779548794 @default.
- W2132063519 hasConceptScore W2132063519C2779629538 @default.
- W2132063519 hasConceptScore W2132063519C55493867 @default.
- W2132063519 hasConceptScore W2132063519C86803240 @default.
- W2132063519 hasConceptScore W2132063519C89423630 @default.
- W2132063519 hasConceptScore W2132063519C98274493 @default.
- W2132063519 hasIssue "5" @default.
- W2132063519 hasLocation W21320635191 @default.
- W2132063519 hasLocation W21320635192 @default.
- W2132063519 hasOpenAccess W2132063519 @default.
- W2132063519 hasPrimaryLocation W21320635191 @default.
- W2132063519 hasRelatedWork W1566729005 @default.
- W2132063519 hasRelatedWork W1610897728 @default.
- W2132063519 hasRelatedWork W1700716001 @default.
- W2132063519 hasRelatedWork W1983855168 @default.
- W2132063519 hasRelatedWork W2046533420 @default.
- W2132063519 hasRelatedWork W2054843986 @default.
- W2132063519 hasRelatedWork W2138350991 @default.