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- W2132074955 abstract "T lymphocytes are a key regulatory component of the adaptive immune system. Understanding how the micro- and nano-scale details of the extracellular environment influence T cell activation may have wide impact on the use of T cells for therapeutic purposes. In this article, we examine how the micro- and nano-scale presentation of ligands to cell surface receptors, including microscale organization and nanoscale mobility, influences the activation of T cells. We extend these studies to include the role of cell-generated forces, and the rigidity of the microenvironment, on T cell activation. These approaches enable delivery of defined signals to T cells, a step toward understanding the cell-cell communication in the immune system, and developing micro/nano- and material- engineered systems for tailoring immune responses for adoptive T cell therapies." @default.
- W2132074955 created "2016-06-24" @default.
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- W2132074955 date "2009-01-01" @default.
- W2132074955 modified "2023-10-16" @default.
- W2132074955 title "Nanoengineering of Immune Cell Function" @default.
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- W2132074955 doi "https://doi.org/10.1557/proc-1209-yy03-01" @default.
- W2132074955 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3090082" @default.
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