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- W2132085004 abstract "The core gene regulatory network (GRN) in embryonic stem cells (ESCs) integrates activities of the pro-self-renewal factors Oct4 (Pou5f1), Sox2 and Nanog with that of an inhibitor of self-renewal, Tcf7l1 (Tcf3). The inhibitor function of Tcf7l1 causes dependence on extracellular Wnt/β-catenin signaling activity, making its embryonic role within the ESC GRN unclear. By analyzing intact mouse embryos, we demonstrate that the function of Tcf7l1 is necessary for specification of cell lineages to occur concomitantly with the elaboration of a three-dimensional body plan during gastrulation. In Tcf7l1(-/-) embryos, specification of mesoderm is delayed, effectively uncoupling it from the induction of the primitive streak. Tcf7l1 repressor activity is necessary for a rapid switch in the response of pluripotent cells to Wnt/β-catenin stimulation, from one of self-renewal to a mesoderm specification response. These results identify Tcf7l1 as a unique factor that is necessary in pluripotent cells to prepare them for lineage specification. We suggest that the role of Tcf7l1 in mammals is to inhibit the GRN to ensure the coordination of lineage specification with the dynamic cellular events occurring during gastrulation." @default.
- W2132085004 created "2016-06-24" @default.
- W2132085004 creator A5010015006 @default.
- W2132085004 creator A5023245469 @default.
- W2132085004 creator A5064109868 @default.
- W2132085004 date "2013-04-15" @default.
- W2132085004 modified "2023-10-16" @default.
- W2132085004 title "Tcf7l1 prepares epiblast cells in the gastrulating mouse embryo for lineage specification" @default.
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- W2132085004 doi "https://doi.org/10.1242/dev.087387" @default.
- W2132085004 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3621485" @default.
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