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- W2132104882 abstract "We performed a systematic review and meta-analysis of thyroid function abnormalities associated with seven vascular endothelial growth factor receptor (VEGFR) targeted tyrosine kinase inhibitors (sorafenib, sunitinib, axitinib, cediranib, pazopanib, regorafenib and vandetanib). Eligible studies included randomized Phase II and III trials of patients with solid tumors on sorafenib OR sunitinib OR axitinib OR cediranib OR pazopanib OR regorafenib OR vandetanib; describing events of hypothyroidism or hyperthyroidism. Our search strategy yielded 195 potentially relevant citations on the seven agents from Pubmed/Medline, CENTRAL Cochrane registry and ASCO meeting library. After exclusion of ineligible studies, a total of 12 clinical trials were considered eligible for the meta-analysis, including six sunitinib studies, four cediranib studies and two axitinib studies. Patients treated with these agents had a significantly increased risk of all-grade hypothyroidism and the relative risk (RR) of all-grade hypothyroidism was 3.59 (95% CI = 2.40–5.38, p ≤ 0.0001). Exploratory subgroup analysis showed no effect of tumor types or agent used on the RR of hypothyroidism. Our meta-analysis has demonstrated that these three agents are associated with a significantly increased risk of all-grade hypothyroidism; with no difference – on subgroup analysis – between sunitinib and cediranib. Clinicians should be aware of these risks and perform regular thyroid function monitoring." @default.
- W2132104882 created "2016-06-24" @default.
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- W2132104882 creator A5047085566 @default.
- W2132104882 date "2014-06-13" @default.
- W2132104882 modified "2023-09-23" @default.
- W2132104882 title "Risk of thyroid dysfunction in patients with solid tumors treated with VEGF receptor tyrosine kinase inhibitors: a critical literature review and meta analysis" @default.
- W2132104882 cites W1504745397 @default.
- W2132104882 cites W1849998523 @default.
- W2132104882 cites W1964407943 @default.
- W2132104882 cites W1964977762 @default.
- W2132104882 cites W1965309017 @default.
- W2132104882 cites W1970255472 @default.
- W2132104882 cites W1971837077 @default.
- W2132104882 cites W1973939344 @default.
- W2132104882 cites W1978111504 @default.
- W2132104882 cites W1983150990 @default.
- W2132104882 cites W1994193851 @default.
- W2132104882 cites W1996229105 @default.
- W2132104882 cites W1996515934 @default.
- W2132104882 cites W1998166051 @default.
- W2132104882 cites W1998482951 @default.
- W2132104882 cites W1999966467 @default.
- W2132104882 cites W2003971943 @default.
- W2132104882 cites W2003999835 @default.
- W2132104882 cites W2007586485 @default.
- W2132104882 cites W2008122005 @default.
- W2132104882 cites W2012565837 @default.
- W2132104882 cites W2015054022 @default.
- W2132104882 cites W2023375628 @default.
- W2132104882 cites W2024586523 @default.
- W2132104882 cites W2026544630 @default.
- W2132104882 cites W2026751701 @default.
- W2132104882 cites W2029245845 @default.
- W2132104882 cites W2031162007 @default.
- W2132104882 cites W2032995236 @default.
- W2132104882 cites W2037383303 @default.
- W2132104882 cites W2045429740 @default.
- W2132104882 cites W2047004402 @default.
- W2132104882 cites W2051719959 @default.
- W2132104882 cites W2055613955 @default.
- W2132104882 cites W2064802903 @default.
- W2132104882 cites W2073858660 @default.
- W2132104882 cites W2074503147 @default.
- W2132104882 cites W2087614255 @default.
- W2132104882 cites W2089580059 @default.
- W2132104882 cites W2091983653 @default.
- W2132104882 cites W2098516378 @default.
- W2132104882 cites W2101776780 @default.
- W2132104882 cites W2102590541 @default.
- W2132104882 cites W2103979740 @default.
- W2132104882 cites W2105464202 @default.
- W2132104882 cites W2107328434 @default.
- W2132104882 cites W2107666024 @default.
- W2132104882 cites W2109240520 @default.
- W2132104882 cites W2112524831 @default.
- W2132104882 cites W2114940128 @default.
- W2132104882 cites W2115078104 @default.
- W2132104882 cites W2116922255 @default.
- W2132104882 cites W2116949558 @default.
- W2132104882 cites W2119242310 @default.
- W2132104882 cites W2119501407 @default.
- W2132104882 cites W2123172787 @default.
- W2132104882 cites W2124464299 @default.
- W2132104882 cites W2125435699 @default.
- W2132104882 cites W2127809030 @default.
- W2132104882 cites W2129638180 @default.
- W2132104882 cites W2131528383 @default.
- W2132104882 cites W2132046158 @default.
- W2132104882 cites W2137508065 @default.
- W2132104882 cites W2139684524 @default.
- W2132104882 cites W2140043667 @default.
- W2132104882 cites W2147834058 @default.
- W2132104882 cites W2149456801 @default.
- W2132104882 cites W2150752208 @default.
- W2132104882 cites W2152143404 @default.
- W2132104882 cites W2152194109 @default.
- W2132104882 cites W2153438885 @default.
- W2132104882 cites W2154117685 @default.
- W2132104882 cites W2158474413 @default.
- W2132104882 cites W2159370421 @default.
- W2132104882 cites W2160724351 @default.
- W2132104882 cites W2160875683 @default.
- W2132104882 cites W2162424705 @default.
- W2132104882 cites W2163760444 @default.
- W2132104882 cites W2165630767 @default.
- W2132104882 cites W2167903658 @default.
- W2132104882 cites W2171085327 @default.
- W2132104882 cites W2468996569 @default.
- W2132104882 cites W2470536940 @default.
- W2132104882 doi "https://doi.org/10.1586/14737140.2014.929501" @default.
- W2132104882 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24927771" @default.
- W2132104882 hasPublicationYear "2014" @default.
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