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• W2132113444 abstract "Protein kinase (PK)C theta is a critical regulator of mature T-cell activation and proliferation, being implicated in TCR-triggered nuclear factor (NF)-kappa B activation and providing important survival signals to leukemic T cells. We previously showed that overexpression of pT alpha/pre-TCR and constitutive activation of NF-kappa B characterize the T-cell leukemia/lymphoma developing in Notch3-IC transgenic mice. We report here that PKC theta is a downstream target of Notch3 signaling and that its activation and membrane translocation require a functional pre-TCR in order to trigger NF-kappa B activation in thymocytes and lymphoma cells of transgenic mice. Furthermore, deletion of PKC theta in Notch3-IC transgenic mice reduces the incidence of leukemia, correlating with decreased NF-kappa B activation. This paper therefore suggests that PKC theta mediates the activation of NF-kappa B by pre-TCR in immature thymocytes and contributes to the development of Notch3-dependent T-cell lymphoma." @default.
• W2132113444 created "2016-06-24" @default.
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• W2132113444 date "2004-12-13" @default.
• W2132113444 modified "2023-10-17" @default.
• W2132113444 title "PKCθ mediates pre-TCR signaling and contributes to Notch3-induced T-cell leukemia" @default.
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• W2132113444 doi "https://doi.org/10.1038/sj.onc.1208302" @default.
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