FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2132136625> ?p ?o ?g. }

• W2132136625 endingPage "3080" @default.
• W2132136625 startingPage "3074" @default.
• W2132136625 abstract "Aim of the study Tumour angiogenesis and invasion are key features of glioblastoma multiforme (GBM). Angiogenesis inhibitors increase progression-free survival (PFS) of recurrent GBM patients. VEGF inhibition controls the bulk tumour growth by inhibition of angiogenesis, but does not inhibit the invasive tumour component. We investigated if invasive tumour growth can be controlled by combining anti-VEGF treatment with irradiation of tumour plus surrounding brain in an orthotopic murine model for GBM. Methods and materials GBM cell line U251-NG2 was inoculated through a guide screw in the right frontal lobe of 53 athymic nude mice. Pegaptanib (a slow-releasing aptamer against VEGF) was injected in the tumour bed either or not followed by irradiation treatment with implanted I-125 seeds. Pegaptanib and/or irradiation were compared with sham-treated controls, resulting in four groups of 10–15 mice each. After 6 weeks of treatment, histological analysis was performed on all brains. Results VEGF inhibition by locally deposited pegaptanib decreased tumour blood vessel density, and increased tumour hypoxia. Pegaptanib treatment still allowed the formation of tumour satellites. Irradiation decreased tumour size and suppressed formation of satellites. Combined pegaptanib plus irradiation further increased PFS. Tumour size directly correlated with PFS. Concluding statement The anti-tumour effects of local VEGF inhibition are partially circumvented by the formation of invasive tumour satellites. Additional irradiation is effective in slowing down proliferation of these invasive tumour components." @default.
• W2132136625 created "2016-06-24" @default.
• W2132136625 creator A5004632162 @default.
• W2132136625 creator A5005988690 @default.
• W2132136625 creator A5014923441 @default.
• W2132136625 creator A5019822912 @default.
• W2132136625 creator A5020475778 @default.
• W2132136625 creator A5027956957 @default.
• W2132136625 creator A5030947676 @default.
• W2132136625 creator A5039486054 @default.
• W2132136625 creator A5049708703 @default.
• W2132136625 date "2009-11-01" @default.
• W2132136625 modified "2023-10-16" @default.
• W2132136625 title "Tumour control by whole brain irradiation of anti-VEGF-treated mice bearing intracerebral glioma" @default.
• W2132136625 cites W1490344207 @default.
• W2132136625 cites W1802218256 @default.
• W2132136625 cites W1977887541 @default.
• W2132136625 cites W1978235312 @default.
• W2132136625 cites W1996687959 @default.
• W2132136625 cites W1997365308 @default.
• W2132136625 cites W2000501172 @default.
• W2132136625 cites W2002727873 @default.
• W2132136625 cites W2006202974 @default.
• W2132136625 cites W2018016372 @default.
• W2132136625 cites W2018992636 @default.
• W2132136625 cites W2030193617 @default.
• W2132136625 cites W2031376430 @default.
• W2132136625 cites W2032272026 @default.
• W2132136625 cites W2033128037 @default.
• W2132136625 cites W2033987226 @default.
• W2132136625 cites W2053318593 @default.
• W2132136625 cites W2056285082 @default.
• W2132136625 cites W2068963958 @default.
• W2132136625 cites W2071680171 @default.
• W2132136625 cites W2076424556 @default.
• W2132136625 cites W2088454377 @default.
• W2132136625 cites W2095964037 @default.
• W2132136625 cites W2099087398 @default.
• W2132136625 cites W2099998343 @default.
• W2132136625 cites W2106964830 @default.
• W2132136625 cites W2107866319 @default.
• W2132136625 cites W2108055789 @default.
• W2132136625 cites W2108542368 @default.
• W2132136625 cites W2127745545 @default.
• W2132136625 cites W2130139391 @default.
• W2132136625 cites W2137686302 @default.
• W2132136625 cites W2147535764 @default.
• W2132136625 cites W2150108534 @default.
• W2132136625 cites W2159311956 @default.
• W2132136625 cites W2168414172 @default.
• W2132136625 cites W2172068975 @default.
• W2132136625 cites W2338264812 @default.
• W2132136625 cites W2357135763 @default.
• W2132136625 doi "https://doi.org/10.1016/j.ejca.2009.08.004" @default.
• W2132136625 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19734041" @default.
• W2132136625 hasPublicationYear "2009" @default.
• W2132136625 type Work @default.
• W2132136625 sameAs 2132136625 @default.
• W2132136625 citedByCount "23" @default.
• W2132136625 countsByYear W21321366252012 @default.
• W2132136625 countsByYear W21321366252013 @default.
• W2132136625 countsByYear W21321366252015 @default.
• W2132136625 countsByYear W21321366252017 @default.
• W2132136625 countsByYear W21321366252018 @default.
• W2132136625 countsByYear W21321366252019 @default.
• W2132136625 countsByYear W21321366252020 @default.
• W2132136625 countsByYear W21321366252021 @default.
• W2132136625 countsByYear W21321366252023 @default.
• W2132136625 crossrefType "journal-article" @default.
• W2132136625 hasAuthorship W2132136625A5004632162 @default.
• W2132136625 hasAuthorship W2132136625A5005988690 @default.
• W2132136625 hasAuthorship W2132136625A5014923441 @default.
• W2132136625 hasAuthorship W2132136625A5019822912 @default.
• W2132136625 hasAuthorship W2132136625A5020475778 @default.
• W2132136625 hasAuthorship W2132136625A5027956957 @default.
• W2132136625 hasAuthorship W2132136625A5030947676 @default.
• W2132136625 hasAuthorship W2132136625A5039486054 @default.
• W2132136625 hasAuthorship W2132136625A5049708703 @default.
• W2132136625 hasConcept C126322002 @default.
• W2132136625 hasConcept C142724271 @default.
• W2132136625 hasConcept C2776694085 @default.
• W2132136625 hasConcept C2777512022 @default.
• W2132136625 hasConcept C2777802072 @default.
• W2132136625 hasConcept C2778227246 @default.
• W2132136625 hasConcept C2778271429 @default.
• W2132136625 hasConcept C2780394083 @default.
• W2132136625 hasConcept C2781100027 @default.
• W2132136625 hasConcept C502942594 @default.
• W2132136625 hasConcept C71924100 @default.
• W2132136625 hasConceptScore W2132136625C126322002 @default.
• W2132136625 hasConceptScore W2132136625C142724271 @default.
• W2132136625 hasConceptScore W2132136625C2776694085 @default.
• W2132136625 hasConceptScore W2132136625C2777512022 @default.
• W2132136625 hasConceptScore W2132136625C2777802072 @default.
• W2132136625 hasConceptScore W2132136625C2778227246 @default.
• W2132136625 hasConceptScore W2132136625C2778271429 @default.
• W2132136625 hasConceptScore W2132136625C2780394083 @default.
• W2132136625 hasConceptScore W2132136625C2781100027 @default.

• next