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• W2132136767 endingPage "992" @default.
• W2132136767 startingPage "987" @default.
• W2132136767 abstract "Activin plays important roles in the regulation of vertebrate reproduction. Using zebrafish, Danio rerio, as a model, the present study aimed at investigating the role of activin in the regulation of final oocyte maturation. Administration of recombinant goldfish activin B significantly increased the rate of oocyte maturation in vitro in a dose- and time-dependent manner. The effect of activin seemed to be additive to the effects of gonadotropin (hCG) and 17alpha,20beta-dihydroxyprogesterone, a potent maturation-inducing hormone in teleosts. The specificity of the activin action was confirmed by coincubation with recombinant human follistatin, which completely abolished the stimulatory effect of activin B. Interestingly, follistatin also significantly inhibited hCG-induced oocyte maturation, suggesting that endogenous activin may be a downstream mediator of gonadotropin actions. No effect of activin B was observed in the presence of actinomycin D, indicating that the action of activin may involve changes in transcriptional activity. These results, together with the demonstration that activin and its type II receptor are expressed in the zebrafish ovary, strongly suggest a paracrine/autocrine role for activin in the controlling of final oocyte maturation." @default.
• W2132136767 created "2016-06-24" @default.
• W2132136767 creator A5011297565 @default.
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• W2132136767 date "1999-10-01" @default.
• W2132136767 modified "2023-10-16" @default.
• W2132136767 title "Activin Stimulation of Zebrafish Oocyte Maturation in Vitro and Its Potential Role in Mediating Gonadotropin-Induced Oocyte Maturation1" @default.
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• W2132136767 doi "https://doi.org/10.1095/biolreprod61.4.987" @default.
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