FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2132144189> ?p ?o ?g. }

• W2132144189 endingPage "4250" @default.
• W2132144189 startingPage "4244" @default.
• W2132144189 abstract "Oxyntomodulin is derived from proglucagon processing in the intestine and the central nervous system. To date, no role in the central nervous system has been demonstrated. We report here that oxyntomodulin inhibits refeeding when injected intracerebroventricularly and into the hypothalamic paraventricular nucleus of 24-h fasted rats [intracerebroventricularly and into the paraventricular nucleus, 1 h, oxyntomodulin (1 nmol), 3.1 ± 0.5 g; saline, 6.2 ± 0.4 g; P < 0.005]. In addition, oxyntomodulin inhibits food intake in nonfasted rats injected at the onset of the dark phase (intracerebroventricularly, 1 h: oxyntomodulin, 3 nmol, 1.1 ± 0.19 g vs. saline, 2.3 ± 0.2 g; P < 0.05). This effect of oxyntomodulin on feeding is of a similar time course and magnitude as that of an equimolar dose of glucagon-like peptide-1. Other proglucagon-derived products investigated [glucagon, glicentin (intracerebroventricularly, 3 nmol; into the paraventricular nucleus, 1 nmol), and spacer peptide-1 (intracerebroventricularly and into the paraventricular nucleus, 3 nmol)] had no effect on feeding at any time point examined. The anorectic effect of oxyntomodulin (intracerebroventricularly, 3 nmol; into the paraventricular nucleus, 1 nmol) was blocked when it was coadministered with the glucagon-like peptide-1 receptor antagonist, exendin-(9–39) (intracerebroventricularly, 100 nmol; into the paraventricular nucleus, 10 nmol). However, oxyntomodulin has a lower affinity for the glucagon-like peptide-1 receptor compared with glucagon-like peptide-1 (IC50: oxyntomodulin, 8.2 nm; glucagon-like peptide-1, 0.16 nm). One explanation for this is that there might be an oxyntomodulin receptor to which exendin-(9–39) can also bind and act as an antagonist." @default.
• W2132144189 created "2016-06-24" @default.
• W2132144189 creator A5011196462 @default.
• W2132144189 creator A5014580425 @default.
• W2132144189 creator A5020334174 @default.
• W2132144189 creator A5028656348 @default.
• W2132144189 creator A5033409636 @default.
• W2132144189 creator A5048940211 @default.
• W2132144189 creator A5070020246 @default.
• W2132144189 creator A5083682224 @default.
• W2132144189 date "2001-10-01" @default.
• W2132144189 modified "2023-10-14" @default.
• W2132144189 title "Oxyntomodulin Inhibits Food Intake in the Rat" @default.
• W2132144189 cites W1485562831 @default.
• W2132144189 cites W1507814807 @default.
• W2132144189 cites W1577188597 @default.
• W2132144189 cites W1637070219 @default.
• W2132144189 cites W1909310469 @default.
• W2132144189 cites W1963621734 @default.
• W2132144189 cites W1965340697 @default.
• W2132144189 cites W1970429748 @default.
• W2132144189 cites W1977680116 @default.
• W2132144189 cites W1985701473 @default.
• W2132144189 cites W1993676624 @default.
• W2132144189 cites W1998882505 @default.
• W2132144189 cites W2013082477 @default.
• W2132144189 cites W2027992617 @default.
• W2132144189 cites W2039903441 @default.
• W2132144189 cites W2045364370 @default.
• W2132144189 cites W2049218678 @default.
• W2132144189 cites W2060949491 @default.
• W2132144189 cites W2065867087 @default.
• W2132144189 cites W2074215288 @default.
• W2132144189 cites W2077811226 @default.
• W2132144189 cites W2079665581 @default.
• W2132144189 cites W2080218399 @default.
• W2132144189 cites W2088397165 @default.
• W2132144189 cites W2088495020 @default.
• W2132144189 cites W2090198261 @default.
• W2132144189 cites W2098327527 @default.
• W2132144189 cites W2104763836 @default.
• W2132144189 cites W2105279117 @default.
• W2132144189 cites W2124687416 @default.
• W2132144189 cites W2138867063 @default.
• W2132144189 cites W2140549760 @default.
• W2132144189 cites W2142903571 @default.
• W2132144189 cites W2146581079 @default.
• W2132144189 cites W2152557643 @default.
• W2132144189 cites W2153568541 @default.
• W2132144189 cites W2156627717 @default.
• W2132144189 cites W2164357952 @default.
• W2132144189 doi "https://doi.org/10.1210/endo.142.10.8430" @default.
• W2132144189 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11564680" @default.
• W2132144189 hasPublicationYear "2001" @default.
• W2132144189 type Work @default.
• W2132144189 sameAs 2132144189 @default.
• W2132144189 citedByCount "215" @default.
• W2132144189 countsByYear W21321441892012 @default.
• W2132144189 countsByYear W21321441892013 @default.
• W2132144189 countsByYear W21321441892014 @default.
• W2132144189 countsByYear W21321441892015 @default.
• W2132144189 countsByYear W21321441892016 @default.
• W2132144189 countsByYear W21321441892017 @default.
• W2132144189 countsByYear W21321441892018 @default.
• W2132144189 countsByYear W21321441892019 @default.
• W2132144189 countsByYear W21321441892020 @default.
• W2132144189 countsByYear W21321441892021 @default.
• W2132144189 countsByYear W21321441892022 @default.
• W2132144189 countsByYear W21321441892023 @default.
• W2132144189 crossrefType "journal-article" @default.
• W2132144189 hasAuthorship W2132144189A5011196462 @default.
• W2132144189 hasAuthorship W2132144189A5014580425 @default.
• W2132144189 hasAuthorship W2132144189A5020334174 @default.
• W2132144189 hasAuthorship W2132144189A5028656348 @default.
• W2132144189 hasAuthorship W2132144189A5033409636 @default.
• W2132144189 hasAuthorship W2132144189A5048940211 @default.
• W2132144189 hasAuthorship W2132144189A5070020246 @default.
• W2132144189 hasAuthorship W2132144189A5083682224 @default.
• W2132144189 hasBestOaLocation W21321441891 @default.
• W2132144189 hasConcept C118303440 @default.
• W2132144189 hasConcept C126322002 @default.
• W2132144189 hasConcept C134018914 @default.
• W2132144189 hasConcept C169760540 @default.
• W2132144189 hasConcept C170493617 @default.
• W2132144189 hasConcept C185592680 @default.
• W2132144189 hasConcept C2776398474 @default.
• W2132144189 hasConcept C2777003273 @default.
• W2132144189 hasConcept C2777180221 @default.
• W2132144189 hasConcept C2777369949 @default.
• W2132144189 hasConcept C2777951760 @default.
• W2132144189 hasConcept C2778542361 @default.
• W2132144189 hasConcept C2778563252 @default.
• W2132144189 hasConcept C2779281246 @default.
• W2132144189 hasConcept C2780723820 @default.
• W2132144189 hasConcept C2780768396 @default.
• W2132144189 hasConcept C2780796126 @default.
• W2132144189 hasConcept C2781219945 @default.
• W2132144189 hasConcept C3018685816 @default.

• next