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- W2132144521 abstract "Forty-five years ago, in 1963, Alan Hodgkin, Andrew Huxley, and Sir John Eccles were awarded the Nobel Prize in physiology or medicine for “their discoveries concerning mechanisms involved in excitation and inhibition in the peripheral and central portions of the nerve cell membrane”. They proved that transport of potassium and sodium ions through nerve membranes is possible due to the presence of ion selective channels that control biological electrical signaling, and that the frequency of ion transport through the channels can be as high as 10 8 s −1 . This review gives a short description of the Hodgkin–Huxley model (HH-model) and presents a summary of recent structural and biochemical data regarding the voltage sensitivity of the channels, which do not support a traditional point of view that the channel is a protein structure formed by separate ionic pore and voltage sensor. A new molecular mechanism of voltage gating is suggested. The mechanism is based on the possibility of channel formation with acidic lipids at the protein/lipid interface for both K" @default.
- W2132144521 created "2016-06-24" @default.
- W2132144521 creator A5077152077 @default.
- W2132144521 date "2009-02-20" @default.
- W2132144521 modified "2023-10-07" @default.
- W2132144521 title "Voltage-sensitive ion channels, acidic lipids and Hodgkin–Huxley equations: New ideas 55 years later" @default.
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- W2132144521 cites W1969129798 @default.
- W2132144521 cites W1975537381 @default.
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- W2132144521 cites W1983519301 @default.
- W2132144521 cites W1983523125 @default.
- W2132144521 cites W1984102682 @default.
- W2132144521 cites W1985940938 @default.
- W2132144521 cites W1990323937 @default.
- W2132144521 cites W1991033228 @default.
- W2132144521 cites W1991655565 @default.
- W2132144521 cites W1995207520 @default.
- W2132144521 cites W1996196738 @default.
- W2132144521 cites W1998532197 @default.
- W2132144521 cites W2000054304 @default.
- W2132144521 cites W2000129051 @default.
- W2132144521 cites W2003317590 @default.
- W2132144521 cites W2005496553 @default.
- W2132144521 cites W2008002200 @default.
- W2132144521 cites W2008470626 @default.
- W2132144521 cites W2014895510 @default.
- W2132144521 cites W2015407518 @default.
- W2132144521 cites W2019577996 @default.
- W2132144521 cites W2022309859 @default.
- W2132144521 cites W2024385532 @default.
- W2132144521 cites W2025174361 @default.
- W2132144521 cites W2028811283 @default.
- W2132144521 cites W2033102303 @default.
- W2132144521 cites W2033233860 @default.
- W2132144521 cites W2039010435 @default.
- W2132144521 cites W2039113473 @default.
- W2132144521 cites W2046171926 @default.
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- W2132144521 cites W2059379562 @default.
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- W2132144521 cites W2076693543 @default.
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- W2132144521 cites W2147142035 @default.
- W2132144521 cites W2147992400 @default.
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- W2132144521 cites W2172246975 @default.
- W2132144521 cites W2314104404 @default.
- W2132144521 cites W2317899006 @default.
- W2132144521 cites W2396626475 @default.
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- W2132144521 cites W2413798874 @default.
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- W2132144521 doi "https://doi.org/10.1016/j.memsci.2008.10.024" @default.
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