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• W2132151944 abstract "ABSTRACT The interferon-inducible membrane protein tetherin (Bst-2, or CD317) is an antiviral factor that inhibits enveloped virus release by cross-linking newly formed virus particles to the producing cell. The majority of viruses that are sensitive to tetherin restriction appear to be those that acquire their envelopes at the plasma membrane, although many viruses, including herpesviruses, envelope at intracellular membranes, and the effect of tetherin on such viruses has been less well studied. We investigated the tetherin sensitivity and possible countermeasures of herpes simplex virus 1 (HSV-1). We found that overexpression of tetherin inhibits HSV-1 release and that HSV-1 efficiently depletes tetherin from infected cells. We further show that the virion host shutoff protein (Vhs) is important for depletion of tetherin mRNA and protein and that removal of tetherin compensates for defects in replication and release of a Vhs-null virus. Vhs is known to be important for HSV-1 to evade the innate immune response in vivo . Taken together, our data suggest that tetherin has antiviral activity toward HSV-1 and that the removal of tetherin by Vhs is important for the efficient replication and dissemination of HSV-1." @default.
• W2132151944 created "2016-06-24" @default.
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• W2132151944 date "2013-12-15" @default.
• W2132151944 modified "2023-10-16" @default.
• W2132151944 title "Herpes Simplex Virus 1 Counteracts Tetherin Restriction via Its Virion Host Shutoff Activity" @default.
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• W2132151944 doi "https://doi.org/10.1128/jvi.02167-13" @default.
• W2132151944 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3838292" @default.
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• W2132151944 hasPublicationYear "2013" @default.
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