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- W2132179056 endingPage "605" @default.
- W2132179056 startingPage "587" @default.
- W2132179056 abstract "Type-2 diabetes is associated with impaired glucose clearance by the liver in the postprandial state, and with elevated glucose production in the post-absorptive state. New targets within the liver are currently being investigated for development of antihyperglycaemic drugs for type-2 diabetes. They include glucokinase, which catalyses the first step in glucose metabolism, the glucagon receptor, and enzymes of gluconeogenesis and/or glycogenolysis such as glucose 6-phosphatase, fructose 1,6-bisphosphatase and glycogen phosphorylase. Preclinical studies with candidate drugs on animal models or cell-based assays suggest that these targets have the potential for pharmacological glycaemic control. Data from clinical studies is awaited. Further work is required for better understanding of the implications of targeting these sites in terms of possible side-effects or tachyphylaxis. The advantage of combined targeting of two or more sites within the liver for minimizing side-effects and tachyphylaxis caused by single-site targeting is discussed." @default.
- W2132179056 created "2016-06-24" @default.
- W2132179056 creator A5083106002 @default.
- W2132179056 date "2007-12-01" @default.
- W2132179056 modified "2023-09-26" @default.
- W2132179056 title "New hepatic targets for glycaemic control in diabetes" @default.
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