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• W2132191461 abstract "ABSTRACT Entamoeba histolytica , the protist that causes amebic dysentery and liver abscess, has a truncated Asn-linked glycan ( N -glycan) precursor composed of seven sugars (Man 5 GlcNAc 2 ). Here, we show that glycoproteins with unmodified N -glycans are aggregated and capped on the surface of E. histolytica trophozoites by the antiretroviral lectin cyanovirin-N and then replenished from large intracellular pools. Cyanovirin-N cocaps the Gal/GalNAc adherence lectin, as well as glycoproteins containing O -phosphodiester-linked glycans recognized by an anti-proteophosphoglycan monoclonal antibody. Cyanovirin-N inhibits phagocytosis by E. histolytica trophozoites of mucin-coated beads, a surrogate assay for amebic virulence. For technical reasons, we used the plant lectin concanavalin A rather than cyanovirin-N to enrich secreted and membrane proteins for mass spectrometric identification. E. histolytica glycoproteins with occupied N -glycan sites include Gal/GalNAc lectins, proteases, and 17 previously hypothetical proteins. The latter glycoproteins, as well as 50 previously hypothetical proteins enriched by concanavalin A, may be vaccine targets as they are abundant and unique. In summary, the antiretroviral lectin cyanovirin-N binds to well-known and novel targets on the surface of E. histolytica that are rapidly replenished from large intracellular pools." @default.
• W2132191461 created "2016-06-24" @default.
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• W2132191461 date "2010-11-01" @default.
• W2132191461 modified "2023-09-26" @default.
• W2132191461 title "The Antiretroviral Lectin Cyanovirin-N Targets Well-Known and Novel Targets on the Surface of Entamoeba histolytica Trophozoites" @default.
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• W2132191461 doi "https://doi.org/10.1128/ec.00166-10" @default.
• W2132191461 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2976296" @default.
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