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- W2132206752 abstract "Neurite branching is essential for the establishment of appropriate neuronal connections during development and regeneration. We identify the small GTPase Ral as a mediator of neurite branching. Active Ral promotes neurite branching in cortical and sympathetic neurons, whereas Ral inhibition decreases laminin-induced branching. In addition, depletion of endogenous Ral by RNA interference decreases branching in cortical neurons. The two Ral isoforms, RalA and -B, promote branching through distinct pathways, involving the exocyst complex and phospholipase D, respectively. Finally, Ral-dependent branching is mediated by protein kinase C–dependent phosphorylation of 43-kD growth-associated protein, a crucial molecule involved in pathfinding, plasticity, and regeneration. These findings highlight an important role for Ral in the regulation of neuronal morphology." @default.
- W2132206752 created "2016-06-24" @default.
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- W2132206752 date "2005-12-05" @default.
- W2132206752 modified "2023-10-17" @default.
- W2132206752 title "Ral GTPases regulate neurite branching through GAP-43 and the exocyst complex" @default.
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- W2132206752 doi "https://doi.org/10.1083/jcb.200507061" @default.
- W2132206752 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2171284" @default.
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