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• W2132222969 endingPage "2053" @default.
• W2132222969 startingPage "2051" @default.
• W2132222969 abstract "Persons with the autosomal recessive disorder Bloom syndrome are predisposed to cancers of many types due to loss-of-function mutations in the BLM gene, which encodes a recQ-like helicase. Here we show that mice heterozygous for a targeted null mutation of Blm, the murine homolog of BLM, develop lymphoma earlier than wild-type littermates in response to challenge with murine leukemia virus and develop twice the number of intestinal tumors when crossed with mice carrying a mutation in the Apc tumor suppressor. These observations indicate that Blm is a modifier of tumor formation in the mouse and that Blm haploinsufficiency is associated with tumor predisposition, a finding with important implications for cancer risk in humans." @default.
• W2132222969 created "2016-06-24" @default.
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• W2132222969 date "2002-09-20" @default.
• W2132222969 modified "2023-10-15" @default.
• W2132222969 title "Enhanced Tumor Formation in Mice Heterozygous for <i>Blm</i> Mutation" @default.
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• W2132222969 doi "https://doi.org/10.1126/science.1074340" @default.
• W2132222969 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12242442" @default.
• W2132222969 hasPublicationYear "2002" @default.
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