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- W2132302103 abstract "A quantitative evaluation of the effect of temperature on the interaction of methyl, propyl, and butylparaben, phenol and p-chlorophenol with polysorbate 80 was obtained with an equilibrium dialysis technique utilizing a plexiglas dialysis cell and a semipermeable membrane. Interactions of parabens with polyethylene glycol 4000 have been studied by the solubility method. The binding affinity of polysorbate 80 for the parabens employed decreased with increase in temperature, whereas that of polyethylene glycol 4000 showed an increase. There was no evidence of temperature dependency of the binding of phenol and p-chlorophenol with polysorbate 80. Parachlorophenol showed a greater tendency to interact with polysorbate 80 than with phenol. The significance of these results relative to the possible mechanism of these interactions is considered. A quantitative evaluation of the effect of temperature on the interaction of methyl, propyl, and butylparaben, phenol and p-chlorophenol with polysorbate 80 was obtained with an equilibrium dialysis technique utilizing a plexiglas dialysis cell and a semipermeable membrane. Interactions of parabens with polyethylene glycol 4000 have been studied by the solubility method. The binding affinity of polysorbate 80 for the parabens employed decreased with increase in temperature, whereas that of polyethylene glycol 4000 showed an increase. There was no evidence of temperature dependency of the binding of phenol and p-chlorophenol with polysorbate 80. Parachlorophenol showed a greater tendency to interact with polysorbate 80 than with phenol. The significance of these results relative to the possible mechanism of these interactions is considered." @default.
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- W2132302103 title "Interaction of Some Pharmaceuticals With Macromolecules I" @default.
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- W2132302103 doi "https://doi.org/10.1002/jps.2600530119" @default.
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