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- W2132303455 abstract "A gas-liquid chromatographic procedure employing an alkali flame ionization detector (GLC-AFID) for the quantitation of imipramine and its major active metabolite, desipramine, in plasma was developed. This method validated a previously reported radioimmunoassay for imipramine and desipramine. The GLC-AFID method was also compared with a GLC-mass spectrometry procedure which employed selected ion monitoring (GLC/MS-SIM) in which specific ions for imipramine and desipramine were monitored. The two methods using gas chromatographic separation were shown to be suitable for therapeutic monitoring of these drugs in patients. The direct radioimmunoassay, which measures the total imipramine plus desipramine, is very useful when large numbers of samples are to be analysed rapidly and it compares favorably with the other two analytical procedures." @default.
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- W2132303455 date "1980-09-01" @default.
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- W2132303455 title "Comparison of a New GLC-AFID Method With a GLC-MS Selected Ion Monitoring Technique and a Radioimmunoassay for the Determination of Plasma Concentrations of Imipramine and Desipramine" @default.
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- W2132303455 doi "https://doi.org/10.1093/jat/4.5.237" @default.
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