FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2132304265> ?p ?o ?g. }

• W2132304265 endingPage "2200" @default.
• W2132304265 startingPage "2187" @default.
• W2132304265 abstract "Our recent study demonstrated that sodium arsenite at a clinically relevant dose induced nephrotoxicity in human renal proximal tubular epithelial cell line HK-2, which could be inhibited by natural product 2,3,5,6-tetramethylpyrazine (TMP) with antioxidant activity. The present study demonstrated that arsenic exposure resulted in protein and enzymatic induction of heme oxygenase-1 (HO-1) in dose- and time-dependent manners in HK-2 cells. Blocking HO-1 enzymatic activity by zinc protoporphyrin (ZnPP) augmented arsenic-induced apoptosis, ROS production and mitochondrial dysfunction, suggesting a critical role for HO-1 as a renal protectant in this procession. On the other hand, TMP, upstream of HO-1, inhibited arsenic-induced ROS production and ROS-dependent HO-1 expression. TMP also prevented mitochondria dysfunction and suppressed activation of the intrinsic apoptotic pathway in HK-2 cells. Our results revealed that the regulation of arsenic-induced HO-1 expression was performed through multiple ROS-dependent signal pathways and the corresponding transcription factors, including p38 MAPK and JNK (but not ERK), AP-1, Nrf2 and NF-κB. TMP inhibited arsenic-induced activations of JNK, p38 MAPK, ERK, AP-1 and Nrf2 and block HO-1 protein expression. The present study, furthermore, demonstrated arsenic-induced expression of arsenic response protein 2 (ARS2) that was regulated by p38 MAPK, ERK and NF-κB. To our knowledge, this is the first report showing that ARS2 involved in arsenic-induced nephrotoxicity, while TMP pretreatment prevented such an up-regulation of ARS2 in HK-2 cells. Given ARS2 and HO-1 sharing the similar regulation mechanism, we speculated that ARS2 might also mediate cell survival in this procession. In summary, our study highlighted a role of HO-1 in the protection against arsenic-induced cytotoxicity downstream from the primary targets of TMP and further indicated that TMP may be used as a potential therapeutic agent in the treatment of arsenic-induced nephrotoxicity." @default.
• W2132304265 created "2016-06-24" @default.
• W2132304265 creator A5067197557 @default.
• W2132304265 creator A5072983863 @default.
• W2132304265 creator A5091297456 @default.
• W2132304265 date "2015-09-24" @default.
• W2132304265 modified "2023-10-03" @default.
• W2132304265 title "2,3,5,6-Tetramethylpyrazine (TMP) down-regulated arsenic-induced heme oxygenase-1 and ARS2 expression by inhibiting Nrf2, NF-κB, AP-1 and MAPK pathways in human proximal tubular cells" @default.
• W2132304265 cites W1558262479 @default.
• W2132304265 cites W1600117974 @default.
• W2132304265 cites W1825970932 @default.
• W2132304265 cites W1956598394 @default.
• W2132304265 cites W1964932824 @default.
• W2132304265 cites W1967257674 @default.
• W2132304265 cites W1967828164 @default.
• W2132304265 cites W1968664031 @default.
• W2132304265 cites W1971835114 @default.
• W2132304265 cites W1973181654 @default.
• W2132304265 cites W1973674477 @default.
• W2132304265 cites W1988697030 @default.
• W2132304265 cites W1996134075 @default.
• W2132304265 cites W2003724153 @default.
• W2132304265 cites W2006752200 @default.
• W2132304265 cites W2011075976 @default.
• W2132304265 cites W2011653269 @default.
• W2132304265 cites W2016730049 @default.
• W2132304265 cites W2016987246 @default.
• W2132304265 cites W2018782901 @default.
• W2132304265 cites W2023524211 @default.
• W2132304265 cites W2037544714 @default.
• W2132304265 cites W2041967565 @default.
• W2132304265 cites W2042891907 @default.
• W2132304265 cites W2044334432 @default.
• W2132304265 cites W2050318470 @default.
• W2132304265 cites W2050345313 @default.
• W2132304265 cites W2058491450 @default.
• W2132304265 cites W2064336499 @default.
• W2132304265 cites W2065855710 @default.
• W2132304265 cites W2069899662 @default.
• W2132304265 cites W2070164699 @default.
• W2132304265 cites W2071636177 @default.
• W2132304265 cites W2072036005 @default.
• W2132304265 cites W2082835152 @default.
• W2132304265 cites W2084154512 @default.
• W2132304265 cites W2086412586 @default.
• W2132304265 cites W2088271195 @default.
• W2132304265 cites W2088571042 @default.
• W2132304265 cites W2095891777 @default.
• W2132304265 cites W2102917327 @default.
• W2132304265 cites W2104721556 @default.
• W2132304265 cites W2128405658 @default.
• W2132304265 cites W2138625851 @default.
• W2132304265 cites W2142423276 @default.
• W2132304265 cites W2142706148 @default.
• W2132304265 cites W2150512617 @default.
• W2132304265 cites W2171402499 @default.
• W2132304265 doi "https://doi.org/10.1007/s00204-015-1600-z" @default.
• W2132304265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4808507" @default.
• W2132304265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26404762" @default.
• W2132304265 hasPublicationYear "2015" @default.
• W2132304265 type Work @default.
• W2132304265 sameAs 2132304265 @default.
• W2132304265 citedByCount "39" @default.
• W2132304265 countsByYear W21323042652016 @default.
• W2132304265 countsByYear W21323042652017 @default.
• W2132304265 countsByYear W21323042652018 @default.
• W2132304265 countsByYear W21323042652019 @default.
• W2132304265 countsByYear W21323042652020 @default.
• W2132304265 countsByYear W21323042652021 @default.
• W2132304265 countsByYear W21323042652022 @default.
• W2132304265 countsByYear W21323042652023 @default.
• W2132304265 crossrefType "journal-article" @default.
• W2132304265 hasAuthorship W2132304265A5067197557 @default.
• W2132304265 hasAuthorship W2132304265A5072983863 @default.
• W2132304265 hasAuthorship W2132304265A5091297456 @default.
• W2132304265 hasBestOaLocation W21323042652 @default.
• W2132304265 hasConcept C126189478 @default.
• W2132304265 hasConcept C178790620 @default.
• W2132304265 hasConcept C181199279 @default.
• W2132304265 hasConcept C184235292 @default.
• W2132304265 hasConcept C185592680 @default.
• W2132304265 hasConcept C190283241 @default.
• W2132304265 hasConcept C2776217839 @default.
• W2132304265 hasConcept C2777730290 @default.
• W2132304265 hasConcept C2779219270 @default.
• W2132304265 hasConcept C2779495234 @default.
• W2132304265 hasConcept C2781447869 @default.
• W2132304265 hasConcept C29730261 @default.
• W2132304265 hasConcept C502230775 @default.
• W2132304265 hasConcept C51551487 @default.
• W2132304265 hasConcept C55493867 @default.
• W2132304265 hasConcept C57074206 @default.
• W2132304265 hasConcept C86803240 @default.
• W2132304265 hasConcept C95444343 @default.
• W2132304265 hasConceptScore W2132304265C126189478 @default.
• W2132304265 hasConceptScore W2132304265C178790620 @default.
• W2132304265 hasConceptScore W2132304265C181199279 @default.
• W2132304265 hasConceptScore W2132304265C184235292 @default.

• next