FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2132308144> ?p ?o ?g. }

• W2132308144 abstract "We previously observed that TRAIL induces acquired TRAIL resistance coinciding with increased Akt phosphorylation brought about by the Src-PI3K-Akt signaling pathways and mediated by c-Cbl. c-Cbl, a ubiquitously expressed cytoplasmic adaptor protein, is simultaneously involved in the rapid degradation of TRAIL receptors and Akt phosphorylation during TRAIL treatment. Here, we show that Akt phosphorylation is not exclusively responsible for acquired TRAIL resistance. Akt catalytic activation is known to increase during metabolic oxidative stress, but we show that TRAIL also dramatically induces the catalytic activation of Akt in TRAIL-sensitive cells, but not in TRAIL-resistant cells. This suggests that Akt catalytic activation during TRAIL-induced apoptosis is likely to play a compensatory role in the maintenance of cell homeostasis. In addition, activated p38 and phosphorylated HSP27 were found to act as downstream effector molecules of p38 during TRAIL treatment and were shown to be responsible for increased Akt catalytic and invasive activities." @default.
• W2132308144 created "2016-06-24" @default.
• W2132308144 creator A5005358526 @default.
• W2132308144 creator A5034916569 @default.
• W2132308144 creator A5040610316 @default.
• W2132308144 creator A5050468616 @default.
• W2132308144 creator A5052116679 @default.
• W2132308144 creator A5054318619 @default.
• W2132308144 creator A5085335212 @default.
• W2132308144 date "2011-01-01" @default.
• W2132308144 modified "2023-09-23" @default.
• W2132308144 title "TRAIL-induced caspase/p38 activation is responsible for the increased catalytic and invasive activities of Akt." @default.
• W2132308144 cites W1605283518 @default.
• W2132308144 cites W1625966995 @default.
• W2132308144 cites W1668309971 @default.
• W2132308144 cites W1890393292 @default.
• W2132308144 cites W1964429103 @default.
• W2132308144 cites W1965718993 @default.
• W2132308144 cites W1966308718 @default.
• W2132308144 cites W1973366579 @default.
• W2132308144 cites W1976462601 @default.
• W2132308144 cites W1981555023 @default.
• W2132308144 cites W1985133272 @default.
• W2132308144 cites W1986735026 @default.
• W2132308144 cites W1989644689 @default.
• W2132308144 cites W1990185188 @default.
• W2132308144 cites W1992930337 @default.
• W2132308144 cites W1996325809 @default.
• W2132308144 cites W1996840415 @default.
• W2132308144 cites W2001617515 @default.
• W2132308144 cites W2002353682 @default.
• W2132308144 cites W2003014847 @default.
• W2132308144 cites W2014545259 @default.
• W2132308144 cites W2021323060 @default.
• W2132308144 cites W2022395895 @default.
• W2132308144 cites W2023964913 @default.
• W2132308144 cites W2024306318 @default.
• W2132308144 cites W2033801757 @default.
• W2132308144 cites W2040125444 @default.
• W2132308144 cites W2041205764 @default.
• W2132308144 cites W2045005486 @default.
• W2132308144 cites W2053265248 @default.
• W2132308144 cites W2055588247 @default.
• W2132308144 cites W2063702713 @default.
• W2132308144 cites W2069897341 @default.
• W2132308144 cites W2074189563 @default.
• W2132308144 cites W2074903693 @default.
• W2132308144 cites W2075944299 @default.
• W2132308144 cites W2076732948 @default.
• W2132308144 cites W2084472730 @default.
• W2132308144 cites W2091891010 @default.
• W2132308144 cites W2092058648 @default.
• W2132308144 cites W2094570524 @default.
• W2132308144 cites W2097767970 @default.
• W2132308144 cites W2128629090 @default.
• W2132308144 cites W2133181350 @default.
• W2132308144 cites W2137035181 @default.
• W2132308144 cites W2150491978 @default.
• W2132308144 cites W2151762172 @default.
• W2132308144 cites W2153825747 @default.
• W2132308144 cites W2154904733 @default.
• W2132308144 cites W2388163742 @default.
• W2132308144 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3004145" @default.
• W2132308144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21109947" @default.
• W2132308144 hasPublicationYear "2011" @default.
• W2132308144 type Work @default.
• W2132308144 sameAs 2132308144 @default.
• W2132308144 citedByCount "2" @default.
• W2132308144 countsByYear W21323081442013 @default.
• W2132308144 countsByYear W21323081442018 @default.
• W2132308144 crossrefType "journal-article" @default.
• W2132308144 hasAuthorship W2132308144A5005358526 @default.
• W2132308144 hasAuthorship W2132308144A5034916569 @default.
• W2132308144 hasAuthorship W2132308144A5040610316 @default.
• W2132308144 hasAuthorship W2132308144A5050468616 @default.
• W2132308144 hasAuthorship W2132308144A5052116679 @default.
• W2132308144 hasAuthorship W2132308144A5054318619 @default.
• W2132308144 hasAuthorship W2132308144A5085335212 @default.
• W2132308144 hasConcept C11960822 @default.
• W2132308144 hasConcept C62478195 @default.
• W2132308144 hasConcept C75217442 @default.
• W2132308144 hasConcept C86554907 @default.
• W2132308144 hasConcept C86803240 @default.
• W2132308144 hasConcept C95444343 @default.
• W2132308144 hasConceptScore W2132308144C11960822 @default.
• W2132308144 hasConceptScore W2132308144C62478195 @default.
• W2132308144 hasConceptScore W2132308144C75217442 @default.
• W2132308144 hasConceptScore W2132308144C86554907 @default.
• W2132308144 hasConceptScore W2132308144C86803240 @default.
• W2132308144 hasConceptScore W2132308144C95444343 @default.
• W2132308144 hasLocation W21323081441 @default.
• W2132308144 hasOpenAccess W2132308144 @default.
• W2132308144 hasPrimaryLocation W21323081441 @default.
• W2132308144 hasRelatedWork W1514262699 @default.
• W2132308144 hasRelatedWork W1893019349 @default.
• W2132308144 hasRelatedWork W1967637444 @default.
• W2132308144 hasRelatedWork W1989726813 @default.
• W2132308144 hasRelatedWork W1999397104 @default.
• W2132308144 hasRelatedWork W2032077813 @default.
• W2132308144 hasRelatedWork W2032468814 @default.

• next