FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2132313539> ?p ?o ?g. }

• W2132313539 endingPage "230" @default.
• W2132313539 startingPage "222" @default.
• W2132313539 abstract "Background: We investigated a role for allergic inflammation and psychologic parameters in the development of chronic fatigue syndrome (CFS). Methods: The design was a comparison between subjects with CFS and age- and sex-matched control cohorts. Studies were performed on CFS subjects (n = 18) and control cohorts consisting of normal subjects (n = 11), allergic subjects (n = 14), and individuals with primary depression (n = 12). We quantified cytokines at baseline as cell-associated immunoreactive peptides and as transcripts evaluated by means of semiquantitative RNA-based polymerase chain reactions. Psychologic evaluations included administration of the Diagnostic Interview Schedule, the Structured Clinical Interview, and the Symptom Checklist 90–Revised. Results: Increases in tumor necrosis factor (TNF)-α were identified in individual subjects with CFS (50.1 ± 14.4 pg TNF-α per 107 peripheral blood mononuclear cells [PBMCs]; mean ± SEM) and allergic subjects (41.6 ± 7.6) in comparison with normal subjects (13.1 ± 8.8) (P < .01 and P < .05, respectively). Similar trends were observed for interferon (IFN)-α in allergic subjects (3.0 ± 1.7 pg/107 PBMCs) and subjects with CFS (6.4 ± 3.4) compared with normal subjects (1.9 ± 1.4). A significant increase (P < .05) in TNF-α transcripts was demonstrated between subjects with CFS and depressed subjects. In contrast to these proinflammatory cytokines, both subjects with CFS (2.6 ± 1.8 pg/107 PBMCs) and allergic subjects (3.4 ± 2.8) were associated with a statistically significant (P < .01) decrease in IL-10 concentrations compared with normal subjects (60.2 ± 18.2). As shown in other studies, most of our subjects with CFS were allergic (15 of 18) and therefore presumably demonstrated cytokine gene activation on that basis. The seasonal exacerbation of allergy was associated with a further increase in cellular IFN-α (from 2.1 ± 1.2 to 14.2 ± 4.5 pg/107 PBMCs; P < .05) but no further modulation of TNF-α or IL-10. Similarly, self-reported exacerbations of CFS were associated with a further increase in IFN-α (from 2.5 ± 1.0 to 21.9 ± 7.8; P < .05) and occurred at times of seasonal exposures to allergens. This linkage does not permit making any definitive conclusions regarding a causative influence of either seasonal allergies or the increase in cellular IFN-α with the increase in CFS symptoms. The close association between atopy and CFS led us to speculate that CFS may arise from an abnormal psychologic response to the disordered expression of these proinflammatory and antiinflammatory cytokines. Psychologic variables were predictive of immune status within the CFS sample (65.9% of the variance in immune status; F (3,10) = 6.44, P < .05). Specifically, the absence of a personality disorder but greater endorsement of global psychiatric symptoms was predictive of immune activation. Conclusions: Most of our subjects with CFS were allergic, and the CFS and allergy cohorts were similar in terms of their immune status. However, the CFS subjects could be discriminated by the distinct psychologic profiles among subjects with and without immune activation. We propose that in at least a large subgroup of subjects with CFS who had allergies, the concomitant influences of immune activation brought on by allergic inflammation in an individual with the appropriate psychologic profile may interact to produce the symptoms of CFS. In a psychologically predisposed individual, symptoms associated with allergic inflammation are recognized as illness. (J Allergy Clin Immunol 1998;102:222-30.)" @default.
• W2132313539 created "2016-06-24" @default.
• W2132313539 creator A5001453166 @default.
• W2132313539 creator A5014583298 @default.
• W2132313539 creator A5021564598 @default.
• W2132313539 creator A5063948687 @default.
• W2132313539 creator A5073307910 @default.
• W2132313539 creator A5090769409 @default.
• W2132313539 date "1998-08-01" @default.
• W2132313539 modified "2023-09-26" @default.
• W2132313539 title "Chronic fatigue syndrome: Identification of distinct subgroups on the basis of allergy and psychologic variables" @default.
• W2132313539 cites W1487331723 @default.
• W2132313539 cites W1503200131 @default.
• W2132313539 cites W1565509706 @default.
• W2132313539 cites W1573470869 @default.
• W2132313539 cites W1993492728 @default.
• W2132313539 cites W1999219977 @default.
• W2132313539 cites W2000994164 @default.
• W2132313539 cites W2022832183 @default.
• W2132313539 cites W2050768782 @default.
• W2132313539 cites W2056075120 @default.
• W2132313539 cites W2060599764 @default.
• W2132313539 cites W2064508115 @default.
• W2132313539 cites W2065260348 @default.
• W2132313539 cites W2068712539 @default.
• W2132313539 cites W2082855271 @default.
• W2132313539 cites W2084990572 @default.
• W2132313539 cites W2092192751 @default.
• W2132313539 cites W2115954882 @default.
• W2132313539 cites W2138387587 @default.
• W2132313539 cites W2138995305 @default.
• W2132313539 cites W2150195134 @default.
• W2132313539 cites W2171477408 @default.
• W2132313539 cites W2191654227 @default.
• W2132313539 cites W2312411376 @default.
• W2132313539 cites W2419343657 @default.
• W2132313539 cites W4245712387 @default.
• W2132313539 cites W4254103152 @default.
• W2132313539 doi "https://doi.org/10.1016/s0091-6749(98)70090-9" @default.
• W2132313539 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9723665" @default.
• W2132313539 hasPublicationYear "1998" @default.
• W2132313539 type Work @default.
• W2132313539 sameAs 2132313539 @default.
• W2132313539 citedByCount "84" @default.
• W2132313539 countsByYear W21323135392012 @default.
• W2132313539 countsByYear W21323135392013 @default.
• W2132313539 countsByYear W21323135392014 @default.
• W2132313539 countsByYear W21323135392015 @default.
• W2132313539 countsByYear W21323135392016 @default.
• W2132313539 countsByYear W21323135392017 @default.
• W2132313539 countsByYear W21323135392018 @default.
• W2132313539 countsByYear W21323135392019 @default.
• W2132313539 countsByYear W21323135392020 @default.
• W2132313539 countsByYear W21323135392021 @default.
• W2132313539 countsByYear W21323135392023 @default.
• W2132313539 crossrefType "journal-article" @default.
• W2132313539 hasAuthorship W2132313539A5001453166 @default.
• W2132313539 hasAuthorship W2132313539A5014583298 @default.
• W2132313539 hasAuthorship W2132313539A5021564598 @default.
• W2132313539 hasAuthorship W2132313539A5063948687 @default.
• W2132313539 hasAuthorship W2132313539A5073307910 @default.
• W2132313539 hasAuthorship W2132313539A5090769409 @default.
• W2132313539 hasBestOaLocation W21323135391 @default.
• W2132313539 hasConcept C126322002 @default.
• W2132313539 hasConcept C137061746 @default.
• W2132313539 hasConcept C139719470 @default.
• W2132313539 hasConcept C162324750 @default.
• W2132313539 hasConcept C164027704 @default.
• W2132313539 hasConcept C17991360 @default.
• W2132313539 hasConcept C202751555 @default.
• W2132313539 hasConcept C203014093 @default.
• W2132313539 hasConcept C207480886 @default.
• W2132313539 hasConcept C2776867660 @default.
• W2132313539 hasConcept C2776914184 @default.
• W2132313539 hasConcept C2779566273 @default.
• W2132313539 hasConcept C55493867 @default.
• W2132313539 hasConcept C71924100 @default.
• W2132313539 hasConcept C86803240 @default.
• W2132313539 hasConcept C90924648 @default.
• W2132313539 hasConceptScore W2132313539C126322002 @default.
• W2132313539 hasConceptScore W2132313539C137061746 @default.
• W2132313539 hasConceptScore W2132313539C139719470 @default.
• W2132313539 hasConceptScore W2132313539C162324750 @default.
• W2132313539 hasConceptScore W2132313539C164027704 @default.
• W2132313539 hasConceptScore W2132313539C17991360 @default.
• W2132313539 hasConceptScore W2132313539C202751555 @default.
• W2132313539 hasConceptScore W2132313539C203014093 @default.
• W2132313539 hasConceptScore W2132313539C207480886 @default.
• W2132313539 hasConceptScore W2132313539C2776867660 @default.
• W2132313539 hasConceptScore W2132313539C2776914184 @default.
• W2132313539 hasConceptScore W2132313539C2779566273 @default.
• W2132313539 hasConceptScore W2132313539C55493867 @default.
• W2132313539 hasConceptScore W2132313539C71924100 @default.
• W2132313539 hasConceptScore W2132313539C86803240 @default.
• W2132313539 hasConceptScore W2132313539C90924648 @default.
• W2132313539 hasIssue "2" @default.
• W2132313539 hasLocation W21323135391 @default.
• W2132313539 hasLocation W21323135392 @default.

• next