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• W2132363122 abstract "This study compares the effects of fluid shear on the kinetics, adhesion efficiency, stability, and molecular requirements of polymorphonuclear leukocyte (PMN) binding to two colon adenocarcinoma cell-lines, the CD54-negative/sLe(x)-bearing LS174T cells and the CD54-expressing/sLe(x)-low HCT-8 cells. The efficiency of PMN-colon carcinoma heteroaggregation decreases with increasing shear, with PMNs binding HCT-8 more efficiently than LS174T cells at low shear (50-200 s(-1)). In the low shear regime, CD11b is sufficient to mediate PMN binding to LS174T cells. In contrast, both CD11a and CD11b contribute to PMN-HCT-8 heteroaggregation, with CD54 on HCT-8 cells acting as a CD11a ligand at early time points. At high shear, only PMN-LS174T heteroaggregation occurs, which is initiated by PMN L-selectin binding to a sialylated, O-linked, protease-sensitive ligand on LS174T cells. PMN-LS174T heteroaggregation is primarily dependent on the intercellular contact duration (or shear rate), whereas PMN-HCT-8 binding is a function of both the intercellular contact duration and the applied force (or shear stress). Cumulatively, these studies suggest that fluid shear modulates the kinetics and molecular mechanisms of PMN-colon carcinoma cell aggregation." @default.
• W2132363122 created "2016-06-24" @default.
• W2132363122 creator A5024161381 @default.
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• W2132363122 date "2002-10-01" @default.
• W2132363122 modified "2023-09-24" @default.
• W2132363122 title "Fluid shear- and time-dependent modulation of molecular interactions between PMNs and colon carcinomas" @default.
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• W2132363122 doi "https://doi.org/10.1152/ajpcell.00104.2002" @default.
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