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• W2132397441 abstract "Cytoplasmic polyadenylation plays a key role in the translational control of mRNAs driving biological processes such as gametogenesis, cell-cycle progression, and synaptic plasticity. What determines the distinct time of polyadenylation and extent of translational control of a given mRNA, however, is poorly understood. The polyadenylation-regulated translation is controlled by the cytoplasmic polyadenylation element (CPE) and its binding protein, CPEB, which can assemble both translational repression or activation complexes. Using a combination of mutagenesis and experimental validation of genome-wide computational predictions, we show that the number and relative position of two elements, the CPE and the Pumilio-binding element, with respect to the polyadenylation signal define a combinatorial code that determines whether an mRNA will be translationally repressed by CPEB, as well as the extent and time of cytoplasmic polyadenylation-dependent translational activation." @default.
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• W2132397441 date "2008-02-01" @default.
• W2132397441 modified "2023-10-09" @default.
• W2132397441 title "A Combinatorial Code for CPE-Mediated Translational Control" @default.
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• W2132397441 doi "https://doi.org/10.1016/j.cell.2007.12.038" @default.
• W2132397441 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18267074" @default.
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