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• W2132398051 abstract "Abstract Objectives: To assess changes in body mass and metabolic profiles in patients with first-episode schizophrenia receiving standardised, assured treatment and to identify predictors and moderators of the effects. Methods: We investigated the changes in body mass, fasting blood glucose and lipids in 107 largely antipsychotic naïve, first-episode schizophrenia patients who were treated according to a standard algorithm with long-acting injectable flupenthixol decanoate over 12 months. Results: Eighty-three (78%) participants completed the 12 months of treatment, and 104 (97%) received 100% of the prescribed injections during their participation. There were significant increases in BMI ( P < .0001), waist circumference ( P = 0.0006) and triglycerides ( P = 0.03) and decrease in HDL ( P = 0.005), while systolic ( P = 0.7) and diastolic blood pressure ( P = 0.8), LDL ( P = 0.1), cholesterol ( P = 0.3), and glucose ( P = 0.9) values did not change over time. The triglyceride: HDL ratio increased by 91%. Change in BMI was only correlated with change in triglycerides ( P = .008). The only significant predictor of BMI increase was non-substance abuse ( P = .002). Conclusions: The risks of weight gain and metabolic syndrome associated with antipsychotic treatment in first-episode schizophrenia are not restricted to second generation antipsychotics. This is a global problem, and developing communities may be particularly susceptible." @default.
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• W2132398051 date "2015-02-01" @default.
• W2132398051 modified "2023-09-27" @default.
• W2132398051 title "Changes in Body Mass and Metabolic Profiles in Patients with First-Episode Schizophrenia Treated for 12 Months with A First-Generation Antipsychotic" @default.
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• W2132398051 doi "https://doi.org/10.1016/j.eurpsy.2014.11.013" @default.
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