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- W2132436675 abstract "Elderly humans have increased morbidity and mortality after viral influenza despite immunization. A mouse model of influenza infection was used to search for a more effective way to induce immunity to influenza. Old (18 months) BALB/c mice were more susceptible to influenza pneumonia than young (2 months) BALB/c mice after intranasal challenge with PR/8 influenza virus despite prior immunization with influenza virus. The decreased resistance to live influenza virus challenge was associated with an impaired generation of anti-hemagglutinin antibody and cytotoxic T lymphocytes in old mice. In contrast, immunization of old mice with a recombinant vaccinia virus expressing the PR/8 influenza hemagglutinin gene protected them from intranasal challenge with live influenza virus and generated high levels of anti-PR/8 influenza virus hemagglutinin antibody and PR/8-specific cytotoxic T cells. Recombinant vaccine overcame the age-associated immune defect that follows the administration of conventional viral vaccine." @default.
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- W2132436675 date "1993-08-01" @default.
- W2132436675 modified "2023-09-27" @default.
- W2132436675 title "Recombinant Vaccinia Virus Expressing the PR/8 Influenza Hemagglutinin Gene Overcomes the Impaired Immune Response and Increased Susceptibility of Old Mice to Influenza Infection" @default.
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- W2132436675 doi "https://doi.org/10.1093/infdis/168.2.352" @default.
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