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- W2132468299 abstract "Our recent work on the intestinal metabolism and absorption of cholecystokinin analogs, sulfated C-terminal octapeptide (CCK8; Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe(NH2) = DYSO3HMGWMDFNH2) and tetrapeptide (CCK4; Trp-Met-Asp-Phe(NH2) = WMDFNH2), was extended to investigate the degradative process of these analogs using rabbit jejunum brush-border membrane vesicles and to find a better enzyme-inhibitor system for intestinal absorption of peptide drugs. Various enzyme inhibitors and a lower pH buffer were applied to discover the major enzyme(s) involved in each process. Metabolic pathways showing degradative processes were proposed for both analogs. The major cleavage site occurs at the W1-M2 for CCK4. At least three metabolic pathways occur independently for CCK8 and appear at peptides bonds between G4-W5, M6-D7, and D7-FNH28. Many different enzymes of aminopeptidase, endopeptidase, angiotensin-converting enzyme, metalloenzyme, and others were involved in each process. Identification of more specific yet safe enzyme inhibitors and co-administration of various these inhibitors may lead to further enhancement in intestinal peptide absorption when administered orally." @default.
- W2132468299 created "2016-06-24" @default.
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- W2132468299 date "2002-11-01" @default.
- W2132468299 modified "2023-09-24" @default.
- W2132468299 title "Possible degradative process of cholecystokinin analogs in rabbit jejunum brush-border membrane vesicles" @default.
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- W2132468299 doi "https://doi.org/10.1016/s0024-3205(02)02198-7" @default.
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