Matches in SemOpenAlex for { <https://semopenalex.org/work/W2132470277> ?p ?o ?g. }
- W2132470277 endingPage "5646" @default.
- W2132470277 startingPage "5630" @default.
- W2132470277 abstract "Duplex stem-loops and four-stranded G-quadruplexes have been implicated in (patho)biological processes. Overlap of stem-loop- and quadruplex-forming sequences could give rise to quadruplex–duplex hybrids (QDH), which combine features of both structural forms and could exhibit unique properties. Here, we present a combined genomic and structural study of stem-loop-containing quadruplex sequences (SLQS) in the human genome. Based on a maximum loop length of 20 nt, our survey identified 80 307 SLQS, embedded within 60 172 unique clusters. Our analysis suggested that these should cover close to half of total SLQS in the entire genome. Among these, 48 508 SLQS were strand-specifically located in genic/promoter regions, with the majority of genes displaying a low number of SLQS. Notably, genes containing abundant SLQS clusters were strongly associated with brain tissues. Enrichment analysis of SLQS-positive genes and mapping of SLQS onto transcriptional/mutagenesis hotspots and cancer-associated genes, provided a statistical framework supporting the biological involvements of SLQS. Invitro formation of diverse QDH by selective SLQS hits were successfully verified by nuclear magnetic resonance spectroscopy. Folding topologies of two SLQS were elucidated in detail. We also demonstrated that sequence changes at mutation/single-nucleotide polymorphism loci could affect the structural conformations adopted by SLQS. Thus, our predicted SLQS offer novel insights into the potential involvement of QDH in diverse (patho)biological processes and could represent novel regulatory signals." @default.
- W2132470277 created "2016-06-24" @default.
- W2132470277 creator A5007314004 @default.
- W2132470277 creator A5009068191 @default.
- W2132470277 creator A5010553710 @default.
- W2132470277 creator A5030609437 @default.
- W2132470277 creator A5059673133 @default.
- W2132470277 creator A5061316473 @default.
- W2132470277 creator A5090135303 @default.
- W2132470277 date "2015-05-09" @default.
- W2132470277 modified "2023-09-25" @default.
- W2132470277 title "Duplex stem-loop-containing quadruplex motifs in the human genome: a combined genomic and structural study" @default.
- W2132470277 cites W118988577 @default.
- W2132470277 cites W1484505342 @default.
- W2132470277 cites W1489967197 @default.
- W2132470277 cites W1966306581 @default.
- W2132470277 cites W1967798131 @default.
- W2132470277 cites W1969089197 @default.
- W2132470277 cites W1969583921 @default.
- W2132470277 cites W1975690779 @default.
- W2132470277 cites W1980513386 @default.
- W2132470277 cites W1990635146 @default.
- W2132470277 cites W1991754576 @default.
- W2132470277 cites W1998940503 @default.
- W2132470277 cites W1999687331 @default.
- W2132470277 cites W2001564806 @default.
- W2132470277 cites W2009587501 @default.
- W2132470277 cites W2011428226 @default.
- W2132470277 cites W2014808883 @default.
- W2132470277 cites W2022287291 @default.
- W2132470277 cites W2028609152 @default.
- W2132470277 cites W2032583041 @default.
- W2132470277 cites W2032698727 @default.
- W2132470277 cites W2034064574 @default.
- W2132470277 cites W2039272200 @default.
- W2132470277 cites W2042160423 @default.
- W2132470277 cites W2044279725 @default.
- W2132470277 cites W2047038417 @default.
- W2132470277 cites W2047559641 @default.
- W2132470277 cites W2050913592 @default.
- W2132470277 cites W2052370215 @default.
- W2132470277 cites W2059306569 @default.
- W2132470277 cites W2062395030 @default.
- W2132470277 cites W2062451058 @default.
- W2132470277 cites W2063270472 @default.
- W2132470277 cites W2063733156 @default.
- W2132470277 cites W2063901213 @default.
- W2132470277 cites W2064754959 @default.
- W2132470277 cites W2068310419 @default.
- W2132470277 cites W2070846511 @default.
- W2132470277 cites W2074615820 @default.
- W2132470277 cites W2080103757 @default.
- W2132470277 cites W2080142197 @default.
- W2132470277 cites W2080661557 @default.
- W2132470277 cites W2083703501 @default.
- W2132470277 cites W2087380875 @default.
- W2132470277 cites W2089598395 @default.
- W2132470277 cites W2092424765 @default.
- W2132470277 cites W2094838505 @default.
- W2132470277 cites W2099009604 @default.
- W2132470277 cites W2102212065 @default.
- W2132470277 cites W2116107651 @default.
- W2132470277 cites W2119449687 @default.
- W2132470277 cites W2122732537 @default.
- W2132470277 cites W2122846880 @default.
- W2132470277 cites W2123696077 @default.
- W2132470277 cites W2129522390 @default.
- W2132470277 cites W2130652515 @default.
- W2132470277 cites W2131498592 @default.
- W2132470277 cites W2134179374 @default.
- W2132470277 cites W2137474088 @default.
- W2132470277 cites W2138996527 @default.
- W2132470277 cites W2139032214 @default.
- W2132470277 cites W2147643191 @default.
- W2132470277 cites W2153502242 @default.
- W2132470277 cites W2155439053 @default.
- W2132470277 cites W2155773930 @default.
- W2132470277 cites W2156206373 @default.
- W2132470277 cites W2158217645 @default.
- W2132470277 cites W2164144387 @default.
- W2132470277 cites W2164876360 @default.
- W2132470277 cites W2166630132 @default.
- W2132470277 cites W2166810745 @default.
- W2132470277 cites W2167827709 @default.
- W2132470277 cites W2169745877 @default.
- W2132470277 cites W2171830519 @default.
- W2132470277 cites W2171928459 @default.
- W2132470277 cites W2316088699 @default.
- W2132470277 cites W2316296352 @default.
- W2132470277 cites W2317153190 @default.
- W2132470277 cites W2318033929 @default.
- W2132470277 cites W82311578 @default.
- W2132470277 doi "https://doi.org/10.1093/nar/gkv355" @default.
- W2132470277 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4477648" @default.
- W2132470277 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25958397" @default.
- W2132470277 hasPublicationYear "2015" @default.
- W2132470277 type Work @default.
- W2132470277 sameAs 2132470277 @default.