Matches in SemOpenAlex for { <https://semopenalex.org/work/W2132472016> ?p ?o ?g. }
- W2132472016 endingPage "7227" @default.
- W2132472016 startingPage "7219" @default.
- W2132472016 abstract "Abstract The G protein–coupled protease-activated receptors (PAR) are key signaling components for proteases in vascular biology and tumor progression. To address the contributions of PAR1 and PAR2 to breast cancer development, we established cohorts of mouse mammary tumor virus–polyoma middle T (PyMT) PAR1−/− and PAR2−/− mice, considering that the PyMT model recapitulates aspects of human disease. Appearance of palpable tumors, tumor expansion, and metastasis was indistinguishable between wild-type and PAR1−/− mice. PAR1−/− breast cancer cells were no longer responsive to thrombin in vitro, excluding compensatory up-regulation of alternative thrombin receptors and indicating that thrombin-PAR1 signaling is dispensable in breast tumor microenvironments. In contrast, palpable tumors and multifocal disease developed slower in PAR2−/− mice, and as a consequence of delayed tumor onset, metastasis was reduced. Analysis of early tumors showed persistence of adenomas with delayed appearance of vascularized adenocarcinomas in PAR2−/− mice. Furthermore, CXCL1 production by early PAR2−/− tumors was reduced. These results are consistent with previous xenograft data that implicated breast cancer PAR2 signaling in the induction of proangiogenic growth factors and chemokines. This study establishes that protease signaling contributes to mammary tumor development and that PAR2, rather than the thrombin receptor PAR1, plays a crucial role in the angiogenic switch. [Cancer Res 2008;68(17):7219–27]" @default.
- W2132472016 created "2016-06-24" @default.
- W2132472016 creator A5005286957 @default.
- W2132472016 creator A5038622138 @default.
- W2132472016 creator A5044188173 @default.
- W2132472016 creator A5050874021 @default.
- W2132472016 creator A5065132298 @default.
- W2132472016 creator A5074449195 @default.
- W2132472016 creator A5080804656 @default.
- W2132472016 date "2008-08-28" @default.
- W2132472016 modified "2023-10-17" @default.
- W2132472016 title "Protease-Activated Receptor (PAR) 2, but not PAR1, Signaling Promotes the Development of Mammary Adenocarcinoma in Polyoma Middle T Mice" @default.
- W2132472016 cites W1963830683 @default.
- W2132472016 cites W1969327218 @default.
- W2132472016 cites W1984352482 @default.
- W2132472016 cites W1985473224 @default.
- W2132472016 cites W1989042624 @default.
- W2132472016 cites W1989701695 @default.
- W2132472016 cites W2003714769 @default.
- W2132472016 cites W2014164476 @default.
- W2132472016 cites W2022995264 @default.
- W2132472016 cites W2024120478 @default.
- W2132472016 cites W2026410953 @default.
- W2132472016 cites W2034967434 @default.
- W2132472016 cites W2035362880 @default.
- W2132472016 cites W2039568250 @default.
- W2132472016 cites W2039926575 @default.
- W2132472016 cites W2042082129 @default.
- W2132472016 cites W2047237481 @default.
- W2132472016 cites W2047655212 @default.
- W2132472016 cites W2050221835 @default.
- W2132472016 cites W2055792439 @default.
- W2132472016 cites W2063742002 @default.
- W2132472016 cites W2068773189 @default.
- W2132472016 cites W2074016597 @default.
- W2132472016 cites W2082833890 @default.
- W2132472016 cites W2089258206 @default.
- W2132472016 cites W2100733055 @default.
- W2132472016 cites W2101137688 @default.
- W2132472016 cites W2104104624 @default.
- W2132472016 cites W2111449140 @default.
- W2132472016 cites W2116665656 @default.
- W2132472016 cites W2119281015 @default.
- W2132472016 cites W2119542456 @default.
- W2132472016 cites W2129311237 @default.
- W2132472016 cites W2129594822 @default.
- W2132472016 cites W2139005650 @default.
- W2132472016 cites W2141445384 @default.
- W2132472016 cites W2142226776 @default.
- W2132472016 cites W2160217779 @default.
- W2132472016 cites W2160246910 @default.
- W2132472016 cites W2167505689 @default.
- W2132472016 cites W2167510293 @default.
- W2132472016 cites W2169375165 @default.
- W2132472016 cites W2213385499 @default.
- W2132472016 cites W2318959008 @default.
- W2132472016 cites W2337548499 @default.
- W2132472016 cites W3113181238 @default.
- W2132472016 doi "https://doi.org/10.1158/0008-5472.can-08-0419" @default.
- W2132472016 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2596617" @default.
- W2132472016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18757438" @default.
- W2132472016 hasPublicationYear "2008" @default.
- W2132472016 type Work @default.
- W2132472016 sameAs 2132472016 @default.
- W2132472016 citedByCount "126" @default.
- W2132472016 countsByYear W21324720162012 @default.
- W2132472016 countsByYear W21324720162013 @default.
- W2132472016 countsByYear W21324720162014 @default.
- W2132472016 countsByYear W21324720162015 @default.
- W2132472016 countsByYear W21324720162016 @default.
- W2132472016 countsByYear W21324720162017 @default.
- W2132472016 countsByYear W21324720162018 @default.
- W2132472016 countsByYear W21324720162019 @default.
- W2132472016 countsByYear W21324720162020 @default.
- W2132472016 countsByYear W21324720162021 @default.
- W2132472016 countsByYear W21324720162022 @default.
- W2132472016 countsByYear W21324720162023 @default.
- W2132472016 crossrefType "journal-article" @default.
- W2132472016 hasAuthorship W2132472016A5005286957 @default.
- W2132472016 hasAuthorship W2132472016A5038622138 @default.
- W2132472016 hasAuthorship W2132472016A5044188173 @default.
- W2132472016 hasAuthorship W2132472016A5050874021 @default.
- W2132472016 hasAuthorship W2132472016A5065132298 @default.
- W2132472016 hasAuthorship W2132472016A5074449195 @default.
- W2132472016 hasAuthorship W2132472016A5080804656 @default.
- W2132472016 hasBestOaLocation W21324720161 @default.
- W2132472016 hasConcept C121608353 @default.
- W2132472016 hasConcept C126322002 @default.
- W2132472016 hasConcept C170493617 @default.
- W2132472016 hasConcept C203014093 @default.
- W2132472016 hasConcept C2776187077 @default.
- W2132472016 hasConcept C2777292125 @default.
- W2132472016 hasConcept C2778886182 @default.
- W2132472016 hasConcept C2779013556 @default.
- W2132472016 hasConcept C2779256057 @default.
- W2132472016 hasConcept C2780394083 @default.
- W2132472016 hasConcept C2781182431 @default.
- W2132472016 hasConcept C502942594 @default.