FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2132491515> ?p ?o ?g. }

• W2132491515 endingPage "3792" @default.
• W2132491515 startingPage "3786" @default.
• W2132491515 abstract "To assess the effects of long-term continuous GH treatment on body composition, blood pressure (BP), and lipid metabolism in children with short stature born small for gestational age (SGA), body mass index (BMI), skinfold thickness measurements, systemic BP measurements, and levels of blood lipids were evaluated in 79 children with a baseline age of 3-11 yr with short stature (height SD-score, < -1.88) born SGA (birth length SD-score, < -1.88). Twenty-two of the 79 children were GH deficient (GHD). All children participated in a randomized, double-blind, dose-response multicenter GH trial. Four- and 6-yr data were compared between two GH dosage groups (3 vs. 6 IU/m2 body surface/day). Untreated children with short stature born SGA are lean (mean BMI SD-score, -1.3; mean SD-score skinfolds, -0.8), have a higher systolic BP (SD-score, 0.7) but normal diastolic BP (SD-score, -0.1), and normal lipids (total cholesterol, 4.7 mmol/L; low-density lipoprotein, 2.9 mmol/L; high-density lipoprotein, 1.3 mmol/L) compared with healthy peers. During long-term continuous GH treatment, the BMI normalized without overall changes in sc fat compared with age-matched references, whereas the BP SD-score and the atherogenic index decreased significantly. Although the mean 6-yr increase in height SD-score was significantly higher in the children receiving GH treatment with 6 IU/m2 x day (2.7) than in those receiving treatment with 3 IU/m2 day (2.2), no differences in the changes in BMI, skinfold measurements, BP, and lipids were found between the GH dosage groups. The pretreatment SD-scores for BMI, skinfold, and BP, as well as the lipid levels, were not significantly different between GHD and non-GHD children, but after 6 yr of GH treatment the skinfold SD-score and BP SD-score had decreased significantly more in the GHD than in the non-GHD children. Our data indicate that GH treatment has at least up to 6 yr positive instead of negative effects on body composition, BP, and lipid metabolism. In view of the reported higher risk of cardiovascular diseases in later life in children born SGA, further research into adulthood remains warranted." @default.
• W2132491515 created "2016-06-24" @default.
• W2132491515 creator A5013809975 @default.
• W2132491515 creator A5018145087 @default.
• W2132491515 creator A5035223402 @default.
• W2132491515 date "2000-10-01" @default.
• W2132491515 modified "2023-10-16" @default.
• W2132491515 title "Body Composition, Blood Pressure, and Lipid Metabolism before and during Long-Term Growth Hormone (GH) Treatment in Children with Short Stature Born Small for Gestational Age Either with or without GH Deficiency1" @default.
• W2132491515 cites W1750240496 @default.
• W2132491515 cites W1895532472 @default.
• W2132491515 cites W1966206889 @default.
• W2132491515 cites W1967039104 @default.
• W2132491515 cites W1969105810 @default.
• W2132491515 cites W1972822860 @default.
• W2132491515 cites W1978682854 @default.
• W2132491515 cites W1986181810 @default.
• W2132491515 cites W1988226243 @default.
• W2132491515 cites W1993499576 @default.
• W2132491515 cites W1993887499 @default.
• W2132491515 cites W1995026946 @default.
• W2132491515 cites W1997040166 @default.
• W2132491515 cites W1997778021 @default.
• W2132491515 cites W2001124412 @default.
• W2132491515 cites W2013014315 @default.
• W2132491515 cites W2015838103 @default.
• W2132491515 cites W2016539713 @default.
• W2132491515 cites W2020907234 @default.
• W2132491515 cites W2021538725 @default.
• W2132491515 cites W2024951997 @default.
• W2132491515 cites W2038956529 @default.
• W2132491515 cites W2039132490 @default.
• W2132491515 cites W2042196336 @default.
• W2132491515 cites W2042495189 @default.
• W2132491515 cites W2045385294 @default.
• W2132491515 cites W2051930892 @default.
• W2132491515 cites W2062076719 @default.
• W2132491515 cites W2091002873 @default.
• W2132491515 cites W2091111343 @default.
• W2132491515 cites W2092221037 @default.
• W2132491515 cites W2095519691 @default.
• W2132491515 cites W2098349892 @default.
• W2132491515 cites W2099158394 @default.
• W2132491515 cites W2101811915 @default.
• W2132491515 cites W2109434832 @default.
• W2132491515 cites W2109788909 @default.
• W2132491515 cites W2111409527 @default.
• W2132491515 cites W2130369769 @default.
• W2132491515 cites W2132124609 @default.
• W2132491515 cites W2141027252 @default.
• W2132491515 cites W2152371714 @default.
• W2132491515 cites W2161209070 @default.
• W2132491515 cites W2165596013 @default.
• W2132491515 cites W2173822004 @default.
• W2132491515 cites W2314894676 @default.
• W2132491515 cites W2588446083 @default.
• W2132491515 doi "https://doi.org/10.1210/jcem.85.10.6917" @default.
• W2132491515 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11061539" @default.
• W2132491515 hasPublicationYear "2000" @default.
• W2132491515 type Work @default.
• W2132491515 sameAs 2132491515 @default.
• W2132491515 citedByCount "63" @default.
• W2132491515 countsByYear W21324915152014 @default.
• W2132491515 countsByYear W21324915152015 @default.
• W2132491515 countsByYear W21324915152016 @default.
• W2132491515 countsByYear W21324915152017 @default.
• W2132491515 countsByYear W21324915152018 @default.
• W2132491515 countsByYear W21324915152019 @default.
• W2132491515 countsByYear W21324915152020 @default.
• W2132491515 countsByYear W21324915152021 @default.
• W2132491515 countsByYear W21324915152023 @default.
• W2132491515 crossrefType "journal-article" @default.
• W2132491515 hasAuthorship W2132491515A5013809975 @default.
• W2132491515 hasAuthorship W2132491515A5018145087 @default.
• W2132491515 hasAuthorship W2132491515A5035223402 @default.
• W2132491515 hasBestOaLocation W21324915151 @default.
• W2132491515 hasConcept C126322002 @default.
• W2132491515 hasConcept C134018914 @default.
• W2132491515 hasConcept C2777871287 @default.
• W2132491515 hasConcept C2778135454 @default.
• W2132491515 hasConcept C2778376644 @default.
• W2132491515 hasConcept C2779234561 @default.
• W2132491515 hasConcept C2780221984 @default.
• W2132491515 hasConcept C2780938740 @default.
• W2132491515 hasConcept C2984496839 @default.
• W2132491515 hasConcept C54355233 @default.
• W2132491515 hasConcept C71315377 @default.
• W2132491515 hasConcept C71924100 @default.
• W2132491515 hasConcept C84393581 @default.
• W2132491515 hasConcept C86803240 @default.
• W2132491515 hasConceptScore W2132491515C126322002 @default.
• W2132491515 hasConceptScore W2132491515C134018914 @default.
• W2132491515 hasConceptScore W2132491515C2777871287 @default.
• W2132491515 hasConceptScore W2132491515C2778135454 @default.
• W2132491515 hasConceptScore W2132491515C2778376644 @default.
• W2132491515 hasConceptScore W2132491515C2779234561 @default.
• W2132491515 hasConceptScore W2132491515C2780221984 @default.
• W2132491515 hasConceptScore W2132491515C2780938740 @default.
• W2132491515 hasConceptScore W2132491515C2984496839 @default.

• next