Matches in SemOpenAlex for { <https://semopenalex.org/work/W2132499165> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2132499165 endingPage "135" @default.
- W2132499165 startingPage "129" @default.
- W2132499165 abstract "The aqueous extract of RP-1, which rendered significant protection to whole body irradiated mice, was found to be tumoricidal. The mode of cytotoxic action of RP-1 attributing to its antitumor action was investigated in U 87 cells with special reference to mitochondrial contribution. RP-1 doses above 0.5 microg/ml reduced colonogenic survival (maximum reduction of 62% at 10 microg/ml) and increased the free radical generation, G2/M fraction and apoptotic frequency. Prolonged exposure to RP-1 rendered significant increase in mitochondrial mass. It also reduced mitochondrial membrane potential in a dose and time dependent manner that was restored by verapamil, a Ca+2 channel blocker. Mitochondrial anti-apoptotic proteins Bcl-2 and Hsp-70 levels were also reduced by RP-1 treatment in a dose and time dependent manner. The ability of RP-1 to disrupt mitochondrial structure and function could be responsible for its cytotoxic action." @default.
- W2132499165 created "2016-06-24" @default.
- W2132499165 creator A5002918535 @default.
- W2132499165 creator A5022185572 @default.
- W2132499165 creator A5050066509 @default.
- W2132499165 creator A5057707352 @default.
- W2132499165 date "2004-03-01" @default.
- W2132499165 modified "2023-09-25" @default.
- W2132499165 title "Mitochondrial involvement in RP-1 mediated apoptosis in U 87 cells" @default.
- W2132499165 cites W13193923 @default.
- W2132499165 cites W1560590968 @default.
- W2132499165 cites W178385535 @default.
- W2132499165 cites W1964507340 @default.
- W2132499165 cites W1975070995 @default.
- W2132499165 cites W1990761289 @default.
- W2132499165 cites W1997208169 @default.
- W2132499165 cites W2008237773 @default.
- W2132499165 cites W2020876160 @default.
- W2132499165 cites W2042502745 @default.
- W2132499165 cites W2049011706 @default.
- W2132499165 cites W2053792745 @default.
- W2132499165 cites W2115767485 @default.
- W2132499165 cites W2137617409 @default.
- W2132499165 cites W2317961752 @default.
- W2132499165 cites W4252582034 @default.
- W2132499165 doi "https://doi.org/10.1016/j.biopha.2003.10.002" @default.
- W2132499165 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14992795" @default.
- W2132499165 hasPublicationYear "2004" @default.
- W2132499165 type Work @default.
- W2132499165 sameAs 2132499165 @default.
- W2132499165 citedByCount "5" @default.
- W2132499165 countsByYear W21324991652012 @default.
- W2132499165 crossrefType "journal-article" @default.
- W2132499165 hasAuthorship W2132499165A5002918535 @default.
- W2132499165 hasAuthorship W2132499165A5022185572 @default.
- W2132499165 hasAuthorship W2132499165A5050066509 @default.
- W2132499165 hasAuthorship W2132499165A5057707352 @default.
- W2132499165 hasConcept C121587506 @default.
- W2132499165 hasConcept C154317977 @default.
- W2132499165 hasConcept C178790620 @default.
- W2132499165 hasConcept C181911157 @default.
- W2132499165 hasConcept C185592680 @default.
- W2132499165 hasConcept C190283241 @default.
- W2132499165 hasConcept C202751555 @default.
- W2132499165 hasConcept C2777022698 @default.
- W2132499165 hasConcept C28859421 @default.
- W2132499165 hasConcept C519063684 @default.
- W2132499165 hasConcept C55493867 @default.
- W2132499165 hasConcept C75385678 @default.
- W2132499165 hasConcept C86803240 @default.
- W2132499165 hasConcept C98274493 @default.
- W2132499165 hasConceptScore W2132499165C121587506 @default.
- W2132499165 hasConceptScore W2132499165C154317977 @default.
- W2132499165 hasConceptScore W2132499165C178790620 @default.
- W2132499165 hasConceptScore W2132499165C181911157 @default.
- W2132499165 hasConceptScore W2132499165C185592680 @default.
- W2132499165 hasConceptScore W2132499165C190283241 @default.
- W2132499165 hasConceptScore W2132499165C202751555 @default.
- W2132499165 hasConceptScore W2132499165C2777022698 @default.
- W2132499165 hasConceptScore W2132499165C28859421 @default.
- W2132499165 hasConceptScore W2132499165C519063684 @default.
- W2132499165 hasConceptScore W2132499165C55493867 @default.
- W2132499165 hasConceptScore W2132499165C75385678 @default.
- W2132499165 hasConceptScore W2132499165C86803240 @default.
- W2132499165 hasConceptScore W2132499165C98274493 @default.
- W2132499165 hasIssue "2" @default.
- W2132499165 hasLocation W21324991651 @default.
- W2132499165 hasLocation W21324991652 @default.
- W2132499165 hasOpenAccess W2132499165 @default.
- W2132499165 hasPrimaryLocation W21324991651 @default.
- W2132499165 hasRelatedWork W1973370234 @default.
- W2132499165 hasRelatedWork W2009866554 @default.
- W2132499165 hasRelatedWork W2032518735 @default.
- W2132499165 hasRelatedWork W2087442345 @default.
- W2132499165 hasRelatedWork W2159042716 @default.
- W2132499165 hasRelatedWork W2268564405 @default.
- W2132499165 hasRelatedWork W2353950880 @default.
- W2132499165 hasRelatedWork W3164241571 @default.
- W2132499165 hasRelatedWork W4297879391 @default.
- W2132499165 hasRelatedWork W2886715054 @default.
- W2132499165 hasVolume "58" @default.
- W2132499165 isParatext "false" @default.
- W2132499165 isRetracted "false" @default.
- W2132499165 magId "2132499165" @default.
- W2132499165 workType "article" @default.