FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2132592493> ?p ?o ?g. }

• W2132592493 abstract "Abstract Background During spinal cord development, expression of chicken SEMAPHORIN6A (SEMA6A) is almost exclusively found in the boundary caps at the ventral motor axon exit point and at the dorsal root entry site. The boundary cap cells are derived from a population of late migrating neural crest cells. They form a transient structure at the transition zone between the peripheral nervous system (PNS) and the central nervous system (CNS). Ablation of the boundary cap resulted in emigration of motoneurons from the ventral spinal cord along the ventral roots. Based on its very restricted expression in boundary cap cells, we tested for a role of Sema6A as a gate keeper between the CNS and the PNS. Results Downregulation of Sema6A in boundary cap cells by in ovo RNA interference resulted in motoneurons streaming out of the spinal cord along the ventral roots, and in the failure of dorsal roots to form and segregate properly. PlexinAs interact with class 6 semaphorins and are expressed by both motoneurons and sensory neurons. Knockdown of PlexinA1 reproduced the phenotype seen after loss of Sema6A function both at the ventral motor exit point and at the dorsal root entry site of the lumbosacral spinal cord. Loss of either PlexinA4 or Sema6D function had an effect only at the dorsal root entry site but not at the ventral motor axon exit point. Conclusion Sema6A acts as a gate keeper between the PNS and the CNS both ventrally and dorsally. It is required for the clustering of boundary cap cells at the PNS/CNS interface and, thus, prevents motoneurons from streaming out of the ventral spinal cord. At the dorsal root entry site it organizes the segregation of dorsal roots." @default.
• W2132592493 created "2016-06-24" @default.
• W2132592493 creator A5010405684 @default.
• W2132592493 creator A5037912688 @default.
• W2132592493 creator A5044523429 @default.
• W2132592493 creator A5054206754 @default.
• W2132592493 creator A5067653789 @default.
• W2132592493 date "2007-12-01" @default.
• W2132592493 modified "2023-10-10" @default.
• W2132592493 title "Semaphorin6A acts as a gate keeper between the central and the peripheral nervous system" @default.
• W2132592493 cites W1506635126 @default.
• W2132592493 cites W1514688353 @default.
• W2132592493 cites W1530050876 @default.
• W2132592493 cites W1608418464 @default.
• W2132592493 cites W1804148198 @default.
• W2132592493 cites W1934032455 @default.
• W2132592493 cites W1965936283 @default.
• W2132592493 cites W1966242618 @default.
• W2132592493 cites W1968324171 @default.
• W2132592493 cites W1971858644 @default.
• W2132592493 cites W1973647878 @default.
• W2132592493 cites W1975269220 @default.
• W2132592493 cites W1980771298 @default.
• W2132592493 cites W1982418670 @default.
• W2132592493 cites W1983996634 @default.
• W2132592493 cites W1986142575 @default.
• W2132592493 cites W1987868279 @default.
• W2132592493 cites W1994496767 @default.
• W2132592493 cites W1997791336 @default.
• W2132592493 cites W2000762378 @default.
• W2132592493 cites W2009048143 @default.
• W2132592493 cites W2009329082 @default.
• W2132592493 cites W2012790217 @default.
• W2132592493 cites W2013392911 @default.
• W2132592493 cites W2015781831 @default.
• W2132592493 cites W2016660493 @default.
• W2132592493 cites W2023193192 @default.
• W2132592493 cites W2030936530 @default.
• W2132592493 cites W2032082827 @default.
• W2132592493 cites W2033508386 @default.
• W2132592493 cites W2033712349 @default.
• W2132592493 cites W2041900617 @default.
• W2132592493 cites W2042344049 @default.
• W2132592493 cites W2042524484 @default.
• W2132592493 cites W2052368339 @default.
• W2132592493 cites W2052957716 @default.
• W2132592493 cites W2056650370 @default.
• W2132592493 cites W2058044475 @default.
• W2132592493 cites W2058704055 @default.
• W2132592493 cites W2061566370 @default.
• W2132592493 cites W2062286030 @default.
• W2132592493 cites W2068599628 @default.
• W2132592493 cites W2071356679 @default.
• W2132592493 cites W2077937161 @default.
• W2132592493 cites W2086681358 @default.
• W2132592493 cites W2088007682 @default.
• W2132592493 cites W2088613950 @default.
• W2132592493 cites W2088843431 @default.
• W2132592493 cites W2090487013 @default.
• W2132592493 cites W2092641793 @default.
• W2132592493 cites W2100057436 @default.
• W2132592493 cites W2102147520 @default.
• W2132592493 cites W2112747602 @default.
• W2132592493 cites W2113121713 @default.
• W2132592493 cites W2116044769 @default.
• W2132592493 cites W2117620907 @default.
• W2132592493 cites W2118018041 @default.
• W2132592493 cites W2118372012 @default.
• W2132592493 cites W2119675301 @default.
• W2132592493 cites W2120804633 @default.
• W2132592493 cites W2127558032 @default.
• W2132592493 cites W2130239919 @default.
• W2132592493 cites W2131860275 @default.
• W2132592493 cites W2136178930 @default.
• W2132592493 cites W2139979516 @default.
• W2132592493 cites W2140034535 @default.
• W2132592493 cites W2143515000 @default.
• W2132592493 cites W2159859956 @default.
• W2132592493 cites W2164274213 @default.
• W2132592493 cites W2169305400 @default.
• W2132592493 cites W2169800968 @default.
• W2132592493 cites W2172326736 @default.
• W2132592493 cites W2184848481 @default.
• W2132592493 cites W2266687804 @default.
• W2132592493 cites W2479839861 @default.
• W2132592493 cites W4213217888 @default.
• W2132592493 cites W4253566969 @default.
• W2132592493 doi "https://doi.org/10.1186/1749-8104-2-28" @default.
• W2132592493 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2238753" @default.
• W2132592493 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18088409" @default.
• W2132592493 hasPublicationYear "2007" @default.
• W2132592493 type Work @default.
• W2132592493 sameAs 2132592493 @default.
• W2132592493 citedByCount "92" @default.
• W2132592493 countsByYear W21325924932012 @default.
• W2132592493 countsByYear W21325924932013 @default.
• W2132592493 countsByYear W21325924932014 @default.
• W2132592493 countsByYear W21325924932015 @default.
• W2132592493 countsByYear W21325924932016 @default.
• W2132592493 countsByYear W21325924932017 @default.

• next