FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2132611932> ?p ?o ?g. }

• W2132611932 endingPage "1096" @default.
• W2132611932 startingPage "1074" @default.
• W2132611932 abstract "Gene microarray was used to characterize the molecular environment of leiomyoma and matched myometrium during growth and in response to GnRH analog (GnRHa) therapy as well as GnRHa direct action on primary cultures of leiomyoma and myometrial smooth muscle cells (LSMC and MSMC). Unsupervised and supervised analysis of gene expression values and statistical analysis in R programming with a false discovery rate of P ≤ 0.02 resulted in identification of 153 and 122 differentially expressed genes in leiomyoma and myometrium in untreated and GnRHa-treated cohorts, respectively. The expression of 170 and 164 genes was affected by GnRHa therapy in these tissues compared with their respective untreated group. GnRHa (0.1 μm), in a time-dependent manner (2, 6, and 12 h), targeted the expression of 281 genes (P ≤ 0.005) in LSMC and MSMC, 48 of which genes were found in common with GnRHa-treated tissues. Functional annotations assigned these genes as key regulators of processes involving transcription, translational, signal transduction, structural activities, and apoptosis. We validated the expression of IL-11, early growth response 3, TGF-β-induced factor, TGF-β-inducible early gene response, CITED2 (cAMP response element binding protein-binding protein/p300-interacting transactivator with ED-rich tail), Nur77, growth arrest-specific 1, p27, p57, and G protein-coupled receptor kinase 5, representing cytokine, common transcription factors, cell cycle regulators, and signal transduction, at tissue levels and in LSMC and MSMC in response to GnRHa time-dependent action using real-time PCR, Western blotting, and immunohistochemistry. In conclusion, using different, complementary approaches, we characterized leiomyoma and myometrium molecular fingerprints and identified several previously unrecognized genes as targets of GnRHa action, implying that local expression and activation of these genes may represent features differentiating leiomyoma and myometrial environments during growth and GnRHa-induced regression." @default.
• W2132611932 created "2016-06-24" @default.
• W2132611932 creator A5031138425 @default.
• W2132611932 creator A5042346357 @default.
• W2132611932 creator A5049396596 @default.
• W2132611932 creator A5083302653 @default.
• W2132611932 creator A5089783895 @default.
• W2132611932 date "2005-03-01" @default.
• W2132611932 modified "2023-10-11" @default.
• W2132611932 title "Leiomyoma and Myometrial Gene Expression Profiles and Their Responses to Gonadotropin-Releasing Hormone Analog Therapy" @default.
• W2132611932 cites W1503376671 @default.
• W2132611932 cites W1847582680 @default.
• W2132611932 cites W1968892142 @default.
• W2132611932 cites W1972305847 @default.
• W2132611932 cites W1977510800 @default.
• W2132611932 cites W1978943108 @default.
• W2132611932 cites W1979285366 @default.
• W2132611932 cites W1979588189 @default.
• W2132611932 cites W1981443806 @default.
• W2132611932 cites W1983081948 @default.
• W2132611932 cites W1986072099 @default.
• W2132611932 cites W1986100686 @default.
• W2132611932 cites W1986924305 @default.
• W2132611932 cites W1990883164 @default.
• W2132611932 cites W1992463891 @default.
• W2132611932 cites W1994489610 @default.
• W2132611932 cites W1994847069 @default.
• W2132611932 cites W1995660143 @default.
• W2132611932 cites W2002777789 @default.
• W2132611932 cites W2003407908 @default.
• W2132611932 cites W2010747883 @default.
• W2132611932 cites W2015255690 @default.
• W2132611932 cites W2022779155 @default.
• W2132611932 cites W2035644133 @default.
• W2132611932 cites W2038322223 @default.
• W2132611932 cites W2038979640 @default.
• W2132611932 cites W2039633328 @default.
• W2132611932 cites W2041409241 @default.
• W2132611932 cites W2053061522 @default.
• W2132611932 cites W2061929388 @default.
• W2132611932 cites W2064726837 @default.
• W2132611932 cites W2067911223 @default.
• W2132611932 cites W2069436500 @default.
• W2132611932 cites W2072514099 @default.
• W2132611932 cites W2073500252 @default.
• W2132611932 cites W2075223992 @default.
• W2132611932 cites W2076475787 @default.
• W2132611932 cites W2077616660 @default.
• W2132611932 cites W2079475371 @default.
• W2132611932 cites W2081794745 @default.
• W2132611932 cites W2081835840 @default.
• W2132611932 cites W2083833577 @default.
• W2132611932 cites W2086270483 @default.
• W2132611932 cites W2087367550 @default.
• W2132611932 cites W2088530372 @default.
• W2132611932 cites W2088632210 @default.
• W2132611932 cites W2089262999 @default.
• W2132611932 cites W2095564407 @default.
• W2132611932 cites W2100027477 @default.
• W2132611932 cites W2103414302 @default.
• W2132611932 cites W2108144590 @default.
• W2132611932 cites W2110117792 @default.
• W2132611932 cites W2110377070 @default.
• W2132611932 cites W2114981642 @default.
• W2132611932 cites W2115987354 @default.
• W2132611932 cites W2123047553 @default.
• W2132611932 cites W2128875155 @default.
• W2132611932 cites W2149338375 @default.
• W2132611932 cites W2149811610 @default.
• W2132611932 cites W2150926065 @default.
• W2132611932 cites W2158725585 @default.
• W2132611932 cites W2159851582 @default.
• W2132611932 cites W2160508724 @default.
• W2132611932 cites W2161823671 @default.
• W2132611932 cites W2169110289 @default.
• W2132611932 cites W2171266906 @default.
• W2132611932 cites W2315471026 @default.
• W2132611932 cites W359659477 @default.
• W2132611932 cites W4233879913 @default.
• W2132611932 cites W4240326098 @default.
• W2132611932 cites W4243049035 @default.
• W2132611932 cites W4247043504 @default.
• W2132611932 cites W4294107304 @default.
• W2132611932 doi "https://doi.org/10.1210/en.2004-1384" @default.
• W2132611932 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15604208" @default.
• W2132611932 hasPublicationYear "2005" @default.
• W2132611932 type Work @default.
• W2132611932 sameAs 2132611932 @default.
• W2132611932 citedByCount "47" @default.
• W2132611932 countsByYear W21326119322012 @default.
• W2132611932 countsByYear W21326119322013 @default.
• W2132611932 countsByYear W21326119322014 @default.
• W2132611932 countsByYear W21326119322015 @default.
• W2132611932 countsByYear W21326119322016 @default.
• W2132611932 countsByYear W21326119322019 @default.
• W2132611932 countsByYear W21326119322020 @default.
• W2132611932 countsByYear W21326119322021 @default.
• W2132611932 countsByYear W21326119322022 @default.

• next