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• W2132633210 abstract "<h3>Objectives:</h3> To evaluate the morbidity and mortality of<i>Candida</i>fungemia and to assess the efficacy of low- vs high-dose amphotericin B and fluconazole vs amphotericin B in patients with candidemia. <h3>Methods:</h3> Multicenter, prospective, observational study of 427 consecutive patients with candidemia. <h3>Results:</h3> The mortality rate for patients with candidemia was 34%. The mortality rate for patients with catheter-related candidemia in whom the catheters were retained was significantly higher than that of patients in whom the catheters were removed (41% vs 21%,<i>P</i><.001). We found no overall difference in mortality in patients treated with low-dose (total amphotericin B dose of ≤500 mg) (13%) vs high-dose amphotericin B (total amphotericin B dose of >500 mg) (15%), but the group treated with a low dose had fewer side effects (40%) than those treated with a high dose (55%) (<i>P</i>=.03). Fluconazole was as efficacious as amphotericin B in the therapy of candidemia, even when stratified by risk factors for mortality. Fewer side effects were seen with fluconazole (12%) compared with amphotericin B (44%) (<i>P</i><.001). <h3>Conclusions:</h3> In selected patients with candidemia, low-dose amphotericin B was as efficacious as high-dose amphotericin B. Based on other studies and ours, fluconazole seems to be an alternative therapeutic option to amphotericin B in selected patients. (Arch Intern Med. 1995;155:2429-2435)" @default.
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• W2132633210 date "1995-12-11" @default.
• W2132633210 modified "2023-10-17" @default.
• W2132633210 title "Therapeutic Approaches in Patients With Candidemia" @default.
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• W2132633210 doi "https://doi.org/10.1001/archinte.1995.00430220087009" @default.
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