FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2132636131> ?p ?o ?g. }

• W2132636131 endingPage "367" @default.
• W2132636131 startingPage "351" @default.
• W2132636131 abstract "Histrionicotoxin, a toxin isolated from skin secretions of a Colombian arrow poison frog, Dendrobates histrionicus, decreased the amplitude and time-course of the endplate current, and altered the voltage dependence of the half-decay time. In addition, the toxin produced a characteristic nonlinearity in the current-voltage relationship of the endplate current when 3-s voltage conditioning steps were used. Reduction in time of the conditioning steps to 10 ms made the current-voltage relationship linear. The decrease in peak amplitude of the endplate current (epc) produced by histrionicotoxin measured during long hyperpolarizing conditioning steps was fitted by a single exponential function. The calculated rate constants ranged from 0.03 to 0.14 s-1 and varied with membrane potential at hyperpolarizing levels. The voltage- and time-dependent action of histrionicotoxin does not require an initial activation of receptors by acetylcholine (ACh). The characteristic of the current-voltage relationship can be accounted for by the observed voltage and time dependency of the attenuation of the endplate current amplitude in the presence of histrionicotoxin during long conditioning steps. These effects of histrionicotoxin on the peak amplitude, and on the voltage and time dependence of the epc were concentration-dependent and slowly reversible upon washing out the toxin. Thus, the voltage- and time-dependent action of histrionicotoxin at the endplate is related to an increase in the affinity between the toxin and the ACh receptor-ionic channel complex. This increase in affinity is postulated to be due to a conformational change of the macromolecule in the presence of histrionicotoxin which is demonstrated to be relatively slow, i.e., on the order of tens of seconds." @default.
• W2132636131 created "2016-06-24" @default.
• W2132636131 creator A5016998628 @default.
• W2132636131 creator A5035254476 @default.
• W2132636131 date "1978-09-01" @default.
• W2132636131 modified "2023-10-06" @default.
• W2132636131 title "Voltage- and time-dependent action of histrionicotoxin on the endplate current of the frog muscle." @default.
• W2132636131 cites W1533618603 @default.
• W2132636131 cites W1834078324 @default.
• W2132636131 cites W1966562800 @default.
• W2132636131 cites W1977106724 @default.
• W2132636131 cites W1982729255 @default.
• W2132636131 cites W1985222283 @default.
• W2132636131 cites W1993091017 @default.
• W2132636131 cites W2002913620 @default.
• W2132636131 cites W2009285843 @default.
• W2132636131 cites W2017863533 @default.
• W2132636131 cites W2021461103 @default.
• W2132636131 cites W2024476309 @default.
• W2132636131 cites W2055379426 @default.
• W2132636131 cites W2059013141 @default.
• W2132636131 cites W2066420439 @default.
• W2132636131 cites W2120389819 @default.
• W2132636131 cites W2126725618 @default.
• W2132636131 cites W2129054215 @default.
• W2132636131 cites W2246589194 @default.
• W2132636131 cites W2266135483 @default.
• W2132636131 cites W2410842416 @default.
• W2132636131 cites W2417309611 @default.
• W2132636131 cites W2474589103 @default.
• W2132636131 cites W4253271002 @default.
• W2132636131 doi "https://doi.org/10.1085/jgp.72.3.351" @default.
• W2132636131 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2228541" @default.
• W2132636131 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/308995" @default.
• W2132636131 hasPublicationYear "1978" @default.
• W2132636131 type Work @default.
• W2132636131 sameAs 2132636131 @default.
• W2132636131 citedByCount "50" @default.
• W2132636131 crossrefType "journal-article" @default.
• W2132636131 hasAuthorship W2132636131A5016998628 @default.
• W2132636131 hasAuthorship W2132636131A5035254476 @default.
• W2132636131 hasBestOaLocation W21326361311 @default.
• W2132636131 hasConcept C104317684 @default.
• W2132636131 hasConcept C119599485 @default.
• W2132636131 hasConcept C121332964 @default.
• W2132636131 hasConcept C12554922 @default.
• W2132636131 hasConcept C127413603 @default.
• W2132636131 hasConcept C134018914 @default.
• W2132636131 hasConcept C165801399 @default.
• W2132636131 hasConcept C169760540 @default.
• W2132636131 hasConcept C170493617 @default.
• W2132636131 hasConcept C176704843 @default.
• W2132636131 hasConcept C180205008 @default.
• W2132636131 hasConcept C181911157 @default.
• W2132636131 hasConcept C185263204 @default.
• W2132636131 hasConcept C185592680 @default.
• W2132636131 hasConcept C2775910092 @default.
• W2132636131 hasConcept C2778935311 @default.
• W2132636131 hasConcept C2779535977 @default.
• W2132636131 hasConcept C55493867 @default.
• W2132636131 hasConcept C62520636 @default.
• W2132636131 hasConcept C80161118 @default.
• W2132636131 hasConcept C81370116 @default.
• W2132636131 hasConcept C86803240 @default.
• W2132636131 hasConceptScore W2132636131C104317684 @default.
• W2132636131 hasConceptScore W2132636131C119599485 @default.
• W2132636131 hasConceptScore W2132636131C121332964 @default.
• W2132636131 hasConceptScore W2132636131C12554922 @default.
• W2132636131 hasConceptScore W2132636131C127413603 @default.
• W2132636131 hasConceptScore W2132636131C134018914 @default.
• W2132636131 hasConceptScore W2132636131C165801399 @default.
• W2132636131 hasConceptScore W2132636131C169760540 @default.
• W2132636131 hasConceptScore W2132636131C170493617 @default.
• W2132636131 hasConceptScore W2132636131C176704843 @default.
• W2132636131 hasConceptScore W2132636131C180205008 @default.
• W2132636131 hasConceptScore W2132636131C181911157 @default.
• W2132636131 hasConceptScore W2132636131C185263204 @default.
• W2132636131 hasConceptScore W2132636131C185592680 @default.
• W2132636131 hasConceptScore W2132636131C2775910092 @default.
• W2132636131 hasConceptScore W2132636131C2778935311 @default.
• W2132636131 hasConceptScore W2132636131C2779535977 @default.
• W2132636131 hasConceptScore W2132636131C55493867 @default.
• W2132636131 hasConceptScore W2132636131C62520636 @default.
• W2132636131 hasConceptScore W2132636131C80161118 @default.
• W2132636131 hasConceptScore W2132636131C81370116 @default.
• W2132636131 hasConceptScore W2132636131C86803240 @default.
• W2132636131 hasIssue "3" @default.
• W2132636131 hasLocation W21326361311 @default.
• W2132636131 hasLocation W21326361312 @default.
• W2132636131 hasLocation W21326361313 @default.
• W2132636131 hasLocation W21326361314 @default.
• W2132636131 hasOpenAccess W2132636131 @default.
• W2132636131 hasPrimaryLocation W21326361311 @default.
• W2132636131 hasRelatedWork W1981317180 @default.
• W2132636131 hasRelatedWork W1993251008 @default.
• W2132636131 hasRelatedWork W2002569136 @default.
• W2132636131 hasRelatedWork W2005681750 @default.
• W2132636131 hasRelatedWork W2016491335 @default.

• next