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• W2132638504 abstract "The proper folding of tubulins and their incorporation into microtubules consist of a series of reactions, in which evolutionarily conserved proteins, cofactors A to E, play a vital role. We have cloned a fission yeast gene ( alp41 + ) which encodes a highly conserved small GTP‐binding protein homologous to budding yeast CIN4 and human ARF‐like Arl2 . alp41 + is essential, disruption of which results in microtubule dysfunction and growth polarity defects. Genetic analysis indicates that Alp41 plays a crucial role in the cofactor‐dependent pathway, in which it functions upstream of the cofactor D homologue Alp1 D and possibly in concert with Alp21 E ." @default.
• W2132638504 created "2016-06-24" @default.
• W2132638504 creator A5006004389 @default.
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• W2132638504 date "2000-02-14" @default.
• W2132638504 modified "2023-10-14" @default.
• W2132638504 title "A conserved small GTP‐binding protein Alp41 is essential for the cofactor‐dependent biogenesis of microtubules in fission yeast" @default.
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• W2132638504 doi "https://doi.org/10.1016/s0014-5793(00)01202-3" @default.
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