FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2132653220> ?p ?o ?g. }

• W2132653220 abstract "We have reported that lesion of the organum vasculosum of the lamina terminalis (OVLT) has no effect on basal levels of mean arterial pressure (MAP) but abolishes the hypertensive effects of angiotensin II (AngII) in rats consuming a normal-salt diet. These results suggest that the OVLT does not contribute to regulation of MAP under conditions of normal salt intake, but it is an important brain site for the hypertensive actions of AngII. The OVLT has been proposed as a major sodium sensor in the brain and the hypertensive effects of AngII are exacerbated by high-salt intake. Therefore, the objective of this study was to investigate the role of the OVLT during AngII-induced hypertension in rats fed a high-salt diet. Male Sprague-Dawley rats underwent sham (Sham; n = 9) or OVLT lesion (OVLTx; n = 8) surgery and were placed on a high-salt (2% NaCl) diet. MAP was measured by radio telemetry during three control days, 10 days of AngII infusion (10 ng/kg/min, i.v.), and a 3-day recovery period. MAP was significantly lower in OVLTx (97 ± 2 mmHg) compared to Sham (106 ± 1 mmHg) rats during the control period (P < 0.05). Moreover, the chronic pressor response to AngII was markedly attenuated in OVLTx rats. MAP increased 58 ± 3 mmHg in Sham rats by Day 10 of AngII compared to a 40 ± 7 mmHg increase in OVLTx rats (P < 0.05). We conclude that (1) the OVLT regulates the basal levels of MAP in rats consuming a high-salt and (2) the OVLT is an important brain site of action for the pathogenesis of AngII-salt hypertension in the rat. Supported by HL076312." @default.
• W2132653220 created "2016-06-24" @default.
• W2132653220 creator A5001899763 @default.
• W2132653220 creator A5052320156 @default.
• W2132653220 creator A5080268324 @default.
• W2132653220 creator A5083093021 @default.
• W2132653220 creator A5091827299 @default.
• W2132653220 date "2013-10-01" @default.
• W2132653220 modified "2023-10-02" @default.
• W2132653220 title "OVLT lesion decreases basal arterial pressure and the chronic hypertensive response to AngII in rats on a high-salt diet" @default.
• W2132653220 cites W1532635216 @default.
• W2132653220 cites W1919568594 @default.
• W2132653220 cites W1935889229 @default.
• W2132653220 cites W1975327379 @default.
• W2132653220 cites W1987810684 @default.
• W2132653220 cites W1988388756 @default.
• W2132653220 cites W1990591911 @default.
• W2132653220 cites W1994633018 @default.
• W2132653220 cites W2017416407 @default.
• W2132653220 cites W2019128512 @default.
• W2132653220 cites W2021945956 @default.
• W2132653220 cites W2034068903 @default.
• W2132653220 cites W2037211353 @default.
• W2132653220 cites W2040691279 @default.
• W2132653220 cites W2040848606 @default.
• W2132653220 cites W2055835158 @default.
• W2132653220 cites W2056748604 @default.
• W2132653220 cites W2067321098 @default.
• W2132653220 cites W2072095482 @default.
• W2132653220 cites W2075725962 @default.
• W2132653220 cites W2080414276 @default.
• W2132653220 cites W2090378906 @default.
• W2132653220 cites W2108067086 @default.
• W2132653220 cites W2119523842 @default.
• W2132653220 cites W2143471386 @default.
• W2132653220 cites W2159604112 @default.
• W2132653220 cites W2164232039 @default.
• W2132653220 cites W2216521770 @default.
• W2132653220 cites W2231188160 @default.
• W2132653220 cites W2325316298 @default.
• W2132653220 doi "https://doi.org/10.1002/phy2.128" @default.
• W2132653220 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3841056" @default.
• W2132653220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24303192" @default.
• W2132653220 hasPublicationYear "2013" @default.
• W2132653220 type Work @default.
• W2132653220 sameAs 2132653220 @default.
• W2132653220 citedByCount "22" @default.
• W2132653220 countsByYear W21326532202014 @default.
• W2132653220 countsByYear W21326532202015 @default.
• W2132653220 countsByYear W21326532202016 @default.
• W2132653220 countsByYear W21326532202017 @default.
• W2132653220 countsByYear W21326532202018 @default.
• W2132653220 countsByYear W21326532202020 @default.
• W2132653220 countsByYear W21326532202021 @default.
• W2132653220 countsByYear W21326532202022 @default.
• W2132653220 countsByYear W21326532202023 @default.
• W2132653220 crossrefType "journal-article" @default.
• W2132653220 hasAuthorship W2132653220A5001899763 @default.
• W2132653220 hasAuthorship W2132653220A5052320156 @default.
• W2132653220 hasAuthorship W2132653220A5080268324 @default.
• W2132653220 hasAuthorship W2132653220A5083093021 @default.
• W2132653220 hasAuthorship W2132653220A5091827299 @default.
• W2132653220 hasBestOaLocation W21326532201 @default.
• W2132653220 hasConcept C126322002 @default.
• W2132653220 hasConcept C134018914 @default.
• W2132653220 hasConcept C141071460 @default.
• W2132653220 hasConcept C198710026 @default.
• W2132653220 hasConcept C2776452961 @default.
• W2132653220 hasConcept C2777953023 @default.
• W2132653220 hasConcept C2778024521 @default.
• W2132653220 hasConcept C2779306644 @default.
• W2132653220 hasConcept C2780248250 @default.
• W2132653220 hasConcept C2781156865 @default.
• W2132653220 hasConcept C2908929049 @default.
• W2132653220 hasConcept C529278444 @default.
• W2132653220 hasConcept C71924100 @default.
• W2132653220 hasConcept C84393581 @default.
• W2132653220 hasConceptScore W2132653220C126322002 @default.
• W2132653220 hasConceptScore W2132653220C134018914 @default.
• W2132653220 hasConceptScore W2132653220C141071460 @default.
• W2132653220 hasConceptScore W2132653220C198710026 @default.
• W2132653220 hasConceptScore W2132653220C2776452961 @default.
• W2132653220 hasConceptScore W2132653220C2777953023 @default.
• W2132653220 hasConceptScore W2132653220C2778024521 @default.
• W2132653220 hasConceptScore W2132653220C2779306644 @default.
• W2132653220 hasConceptScore W2132653220C2780248250 @default.
• W2132653220 hasConceptScore W2132653220C2781156865 @default.
• W2132653220 hasConceptScore W2132653220C2908929049 @default.
• W2132653220 hasConceptScore W2132653220C529278444 @default.
• W2132653220 hasConceptScore W2132653220C71924100 @default.
• W2132653220 hasConceptScore W2132653220C84393581 @default.
• W2132653220 hasFunder F4320309636 @default.
• W2132653220 hasIssue "5" @default.
• W2132653220 hasLocation W21326532201 @default.
• W2132653220 hasLocation W21326532202 @default.
• W2132653220 hasLocation W21326532203 @default.
• W2132653220 hasLocation W21326532204 @default.
• W2132653220 hasOpenAccess W2132653220 @default.
• W2132653220 hasPrimaryLocation W21326532201 @default.
• W2132653220 hasRelatedWork W2016647631 @default.

• next