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- W2132653532 abstract "Abstract Background The human HERV-W multicopy family includes a unique proviral locus, termed ERVWE1, whose full-length envelope ORF was preserved through evolution by the action of a selective pressure. The encoded Env protein (Syncytin) is involved in hominoid placental physiology. Results In order to infer the natural history of this domestication process, a comparative genomic analysis of the human 7q21.2 syntenic regions in eutherians was performed. In primates, this region was progressively colonized by LTR-elements, leading to two different evolutionary pathways in Cercopithecidae and Hominidae, a genetic drift versus a domestication, respectively. Conclusion The preservation in Hominoids of a genomic structure consisting in the juxtaposition of a retrotransposon-derived MaLR LTR and the ERVWE1 provirus suggests a functional link between both elements." @default.
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- W2132653532 date "2005-09-22" @default.
- W2132653532 modified "2023-10-18" @default.
- W2132653532 title "Natural history of the ERVWE1 endogenous retroviral locus" @default.
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- W2132653532 doi "https://doi.org/10.1186/1742-4690-2-57" @default.
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