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- W2132658045 abstract "Retinal ischemia and oxidative stress lead to neuronal death in many ocular pathologies. Recently, we found that lutein, an oxy-carotenoid, protected the inner retina from ischemia/reperfusion injury. However, it is uncertain whether lutein directly protects retinal ganglion cells (RGCs). Here, an in vitro model of hypoxia and oxidative stress was used to further investigate the neuroprotective role of lutein in RGCs. Cobalt chloride (CoCl(2)) and hydrogen peroxide (H(2)O(2)) were added to a transformed RGC cell line, RGC-5, to induce chemical hypoxia and oxidative stress, respectively. Either lutein or vehicle was added to cultured cells. A higher cell count was observed in the lutein-treated cells compared with the vehicle-treated cells. Our data from this in vitro model revealed that lutein might protect RGC-5 cells from damage when exposed to either CoCl(2)-induced chemical hypoxia or H(2)O(2)-induced oxidative stress. These results suggest that lutein may play a role as a neuroprotectant." @default.
- W2132658045 created "2016-06-24" @default.
- W2132658045 creator A5017349166 @default.
- W2132658045 creator A5069372541 @default.
- W2132658045 date "2010-05-11" @default.
- W2132658045 modified "2023-10-01" @default.
- W2132658045 title "Lutein Protects RGC-5 Cells Against Hypoxia and Oxidative Stress" @default.
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- W2132658045 doi "https://doi.org/10.3390/ijms11052109" @default.
- W2132658045 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2885097" @default.
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