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- W2132670211 abstract "Killer immunoglobulin-like receptor (KIR)-ligand incompatibility in the graft-versus-host direction is associated with improved outcome in patients receiving hematopoietic stem cell transplants. Fetal–maternal microchimerism has been suggested to mediate acquired fetal–maternal tolerance. The goal of this study was to determine the clinical efficacy of KIR-ligand incompatibility and fetal–maternal microchimerism for interleukin-2-activated haploidentical peripheral blood stem cells (haplo-PBSCs) treatment for patients with advanced solid cancer. Forty-two (42) patients with advanced stage of solid cancer and refractory to standard chemotherapy were treated with haplo-PBSCs donated by their parents or children. Human leukocyte antigen typing, fetal–maternal microchimerism status, and engraftment were detected. Clinical outcomes including overall survival (OS), progression-free survival (PFS), and Karnofsky Performance Status (KPS) level were evaluated. Patients receiving haplo-PBSCs treatment with KIR-ligand incompatibility in the graft-versus-host direction had higher probability of OS (26.8 ± 3.1 months) and PFS (13.4 ± 1.3 months) when compared with those with KIR ligand compatibility (OS: 17.4 ± 3.0 months, p < 0.05 and PSF: 8.0 ± 0.9 months, p < 0.05). Further, OS (31.2 ± 4.3 months), PFS (14.7 ± 2.2 months), and KPS increase (27 points) in the microchimerism-positive group was improved compared with that in the microchimerism-negative group (OS: 16.9 ± 3.8 months, p < 0.01, PFS: 5.6 ± 1.4 months, p < 0.01, and KPS increase: 15 points, p < 0.01). Therefore, KIR-ligand incompatibility and fetal–maternal microchimerism are associated with better outcome for haplo-PBSCs treatment." @default.
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- W2132670211 date "2010-12-01" @default.
- W2132670211 modified "2023-09-22" @default.
- W2132670211 title "Fetal–Maternal Microchimerism Enhances the Survival Effect of Interleukin-2-Activated Haploidentical Peripheral Blood Stem Cell Treatment in Patients with Advanced Solid Cancer" @default.
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- W2132670211 doi "https://doi.org/10.1089/cbr.2010.0770" @default.
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