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- W2132698082 abstract "<h3>BACKGROUND:</h3> Properly titrated opiates decrease respiratory rate but do not affect tidal volume or induce respiratory acidosis. <h3>OBJECTIVE:</h3> To determine whether remifentanil improves breathing pattern or reduces inspiratory effort in patients with acute respiratory failure and tachypnea or rapid shallow breathing. <h3>METHODS:</h3> We studied 14 patients who developed tachypnea and/or rapid shallow breathing if the pressure support level was reduced. During pressure support ventilation, each patient received 30-min infusions, separated by 30 min, of remifentanil and placebo. Measurements were obtained before commencing and before stopping each infusion, and after 3 min of unassisted breathing. The main outcomes were rapid shallow breathing index and change in pressure-time product. <h3>RESULTS:</h3> Remifentanil did not significantly affect tidal volume. During pressure support ventilation, remifentanil infusion reduced respiratory rate, pressure-time product, and cardiovascular double product (heart rate × systolic arterial pressure) without modifying the sedation score. Mean P<sub>aCO<sub>2</sub></sub> showed a small and clinically negligible increase during remifentanil, but P<sub>aCO<sub>2</sub></sub> increased more in the hypercapnic patients than in the normocapnic patients. Remifentanil reduced the rapid shallow breathing index after 3 min of unassisted breathing. <h3>CONCLUSIONS:</h3> Remifentanil improved respiratory pattern and decreased inspiratory muscles effort in patients with tachypnea or rapid shallow breathing, but did not affect oxygenation or sedation. Though the acid-base balance did not show clinically relevant changes on average, we cannot exclude the possibility that remifentanil might prolong weaning in hypercapnic patients. (ClinicalTrials.gov registration NCT00665119)" @default.
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- W2132698082 date "2011-06-01" @default.
- W2132698082 modified "2023-09-28" @default.
- W2132698082 title "Remifentanil Improves Breathing Pattern and Reduces Inspiratory Workload in Tachypneic Patients" @default.
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- W2132698082 doi "https://doi.org/10.4187/respcare.01014" @default.
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