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• W2132738255 abstract "Abstract Although the CpG island methylator phenotype (CIMP) was first identified and has been most extensively studied in colorectal cancer, the term “CIMP” has been repeatedly used over the past decade to describe CpG island promoter methylation in other tumor types, including bladder, breast, endometrial, gastric, glioblastoma (gliomas), hepatocellular, lung, ovarian, pancreatic, renal cell, and prostate cancers, as well as for leukemia, melanoma, duodenal adenocarninomas, adrenocortical carcinomas, and neuroblastomas. CIMP has been reported to be useful for predicting prognosis and response to treatment in a variety of tumor types, but it remains unclear whether or not CIMP is a universal phenomenon across human neoplasia or if there should be cancer-specific definitions of the phenotype. Recently, it was shown that somatic isocitrate dehydrogenase-1 (IDH1) mutations, frequently observed in gliomas, establish CIMP in primary human astrocytes by remodeling the methylome. Interestingly, somatic IDH1 and IDH2 mutations, and loss-of-function mutations in ten-eleven translocation (TET) methylcytosine dioxygenase-2 (TET2) associated with a hypermethylation phenotype, are also found in multiple enchondromas of patients with Ollier disease and Mafucci syndrome, and leukemia, respectively. These data provide the first clues for the elucidation of a molecular basis for CIMP. Although CIMP appears as a phenomenon that occurs in various cancer types, the definition is poorly defined and differs for each tumor. The current perspective discusses the use of the term CIMP in cancer, its significance in clinical practice, and future directions that may aid in identifying the true cause and definition of CIMP in different forms of human neoplasia. Cancer Res; 73(19); 5858–68. ©2013 AACR." @default.
• W2132738255 created "2016-06-24" @default.
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• W2132738255 date "2013-10-01" @default.
• W2132738255 modified "2023-10-16" @default.
• W2132738255 title "The CpG Island Methylator Phenotype: What's in a Name?" @default.
• W2132738255 cites W1755052449 @default.
• W2132738255 cites W1894057315 @default.
• W2132738255 cites W1963567995 @default.
• W2132738255 cites W1965151472 @default.
• W2132738255 cites W1965262464 @default.
• W2132738255 cites W1968264445 @default.
• W2132738255 cites W1971937022 @default.
• W2132738255 cites W1972218893 @default.
• W2132738255 cites W1974840866 @default.
• W2132738255 cites W1981980694 @default.
• W2132738255 cites W1984746891 @default.
• W2132738255 cites W1988756388 @default.
• W2132738255 cites W1989398321 @default.
• W2132738255 cites W1989810154 @default.
• W2132738255 cites W1990454839 @default.
• W2132738255 cites W1995675594 @default.
• W2132738255 cites W1997023156 @default.
• W2132738255 cites W2002218976 @default.
• W2132738255 cites W2007808560 @default.
• W2132738255 cites W2008069197 @default.
• W2132738255 cites W2008758335 @default.
• W2132738255 cites W2011376261 @default.
• W2132738255 cites W2012488194 @default.
• W2132738255 cites W2018041848 @default.
• W2132738255 cites W2019527553 @default.
• W2132738255 cites W2027444736 @default.
• W2132738255 cites W2027532999 @default.
• W2132738255 cites W2029746613 @default.
• W2132738255 cites W2030747407 @default.
• W2132738255 cites W2033126020 @default.
• W2132738255 cites W2035409103 @default.
• W2132738255 cites W2042271589 @default.
• W2132738255 cites W2043997002 @default.
• W2132738255 cites W2054818135 @default.
• W2132738255 cites W2060647968 @default.
• W2132738255 cites W2065571280 @default.
• W2132738255 cites W2066154261 @default.
• W2132738255 cites W2068278696 @default.
• W2132738255 cites W2074174832 @default.
• W2132738255 cites W2074200851 @default.
• W2132738255 cites W2077475263 @default.
• W2132738255 cites W2078972833 @default.
• W2132738255 cites W2080452140 @default.
• W2132738255 cites W2082028687 @default.
• W2132738255 cites W2082475821 @default.
• W2132738255 cites W2084469088 @default.
• W2132738255 cites W2084945856 @default.
• W2132738255 cites W2086775982 @default.
• W2132738255 cites W2091553610 @default.
• W2132738255 cites W2092169530 @default.
• W2132738255 cites W2093272868 @default.
• W2132738255 cites W2095785927 @default.
• W2132738255 cites W2096796171 @default.
• W2132738255 cites W2105528101 @default.
• W2132738255 cites W2106505043 @default.
• W2132738255 cites W2107972234 @default.
• W2132738255 cites W2108630708 @default.
• W2132738255 cites W2108956458 @default.
• W2132738255 cites W2109297844 @default.
• W2132738255 cites W2112442017 @default.
• W2132738255 cites W2113437172 @default.
• W2132738255 cites W2114486584 @default.
• W2132738255 cites W2116453600 @default.
• W2132738255 cites W2117424291 @default.
• W2132738255 cites W2118133069 @default.
• W2132738255 cites W2118668725 @default.
• W2132738255 cites W2119652769 @default.
• W2132738255 cites W2120833240 @default.
• W2132738255 cites W2121203184 @default.
• W2132738255 cites W2121239890 @default.
• W2132738255 cites W2124951199 @default.
• W2132738255 cites W2125241873 @default.
• W2132738255 cites W2128146359 @default.
• W2132738255 cites W2131348295 @default.
• W2132738255 cites W2131860315 @default.
• W2132738255 cites W2132327532 @default.
• W2132738255 cites W2136914254 @default.
• W2132738255 cites W2138320521 @default.

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